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Genetic Architecture Underlying Nascent Speciation—The Evolution of Eurasian Pigs under Domestication
| Content Provider | Oxford Academic |
|---|---|
| Author | Xie, Hai-Bing Wang, Li-Gang Fan, Chen-Yu Zhang, Long-Chao Adeola, Adeniyi C Yin, Xue Zeng, Zhao-Bang Wang, Li-Xian Zhang, Ya-Ping |
| Copyright Year | 2021 |
| Abstract | Speciation is a process whereby the evolution of reproductive barriers leads to isolated species. Although many studies have addressed large-effect genetic footprints in the advanced stages of speciation, the genetics of reproductive isolation in nascent stage of speciation remains unclear. Here, we show that pig domestication offers an interesting model for studying the early stages of speciation in great details. Pig breeds have not evolved the large X-effect of hybrid incompatibility commonly observed between “good species.” Instead, deleterious epistatic interactions among multiple autosomal loci are common. These weak Dobzhansky–Muller incompatibilities confer partial hybrid inviability with sex biases in crosses between European and East Asian domestic pigs. The genomic incompatibility is enriched in pathways for angiogenesis, androgen receptor signaling and immunity, with an observation of many highly differentiated cis-regulatory variants. Our study suggests that partial hybrid inviability caused by pervasive but weak interactions among autosomal loci may be a hallmark of nascent speciation in mammals. |
| Related Links | https://academic.oup.com/mbe/article-pdf/38/9/3556/39882818/msab117.pdf |
| Ending Page | 3566 |
| Starting Page | 3556 |
| File Format | |
| ISSN | 07374038 |
| e-ISSN | 15371719 |
| DOI | 10.1093/molbev/msab117 |
| Journal | Molecular Biology and Evolution |
| Issue Number | 9 |
| Volume Number | 38 |
| Language | English |
| Publisher | Oxford Academic |
| Publisher Date | 2021-08-23 |
| Access Restriction | Open |
| Subject Keyword | Biological Sciences Evolutionary Biology Molecular and Cell Biology Science and Mathematics Pig Domestication Nascent Speciation Partial Hybrid Inviability Dobzhansky–muller Incompatibility Autosomal Interactions |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Molecular Biology Ecology, Evolution, Behavior and Systematics |
