NDLI: A rare case of extraluminally pedunculated gastrointestinal stromal tumor with postoperative metastasis to pancreas

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A rare case of extraluminally pedunculated gastrointestinal stromal tumor with postoperative metastasis to pancreas

Content Provider	Oxford Academic
Author	Ogawa, Shoko Nishihara, Masayoshi Nakanishi, Takaya Maeda, Tamaki Hirota, Seiichi
Copyright Year	2021
Abstract	The gastrointestinal stromal tumor (GIST) is the most common type of sarcomatous tumor of the gastrointestinal tract. Many GISTs appear as submucosal tumors with intraluminal protrusion. GISTs with malignant features have a high risk of postoperative recurrence or metastasis, usually to the liver or peritoneum. We present a case of gastric GIST with double rarities: arising completely extraluminally with a pedicle and postoperative metastasis to the pancreas. A woman in her seventies diagnosed with a large extraluminal gastric GIST underwent complete removal of the tumor. Nine months later, a solitary metastatic tumor in the pancreas was detected. Imatinib controlled metastasis well for four years before the tumor became resistant. The patient then had a partial pancreatectomy with splenectomy. She is currently free from recurrence. We genetically analyzed the primary and metastatic GISTs and found known mutations related to poor prognosis and imatinib resistance.
Related Links	https://academic.oup.com/jscr/article-pdf/2021/9/rjab422/40442570/rjab422.pdf
File Format	PDF
e-ISSN	20428812
DOI	10.1093/jscr/rjab422
Journal	Journal of Surgical Case Reports
Issue Number	9
Volume Number	2021
Language	English
Publisher	Oxford Academic
Publisher Date	2021-09-01
Access Restriction	Open
Subject Keyword	Medicine and Health Surgery Neoplasms Imatinib Mesylate Gastrointestinal Stromal Tumor Secondary Malignant Neoplasm of Pancreas Neoplasm Metastasis Pancreas Gastric Gastrointestinal Stromal Tumor Mutation Splenectomy Liver Peritoneum Gastrointestinal Tract Pedicle Pancreatectomy
Content Type	Text
Resource Type	Article
Subject	Surgery

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