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Diarrhea-Predominant Irritable Bowel Syndrome: Medical Management Update
| Content Provider | Oxford Academic |
|---|---|
| Author | Andrews, Christopher N Bradette, Marc |
| Copyright Year | 2020 |
| Abstract | Irritable bowel syndrome (IBS) is a prevalent gastrointestinal disorder, which impacts the quality of life, work productivity and social activities of patients. Diarrhea-predominant IBS (IBS-D) is one of several subtypes, and accounts for approximately one third of all cases. Currently available treatments are typically unable to alleviate the cardinal symptoms of IBS-D, including abdominal pain and diarrhea, and a clinical unmet need remains for an effective treatment which simultaneously relieves multiple symptoms. Patients may benefit from a multipronged, individualized approach, including dietary modifications, and psychological and pharmacological therapies. The aim of this review is to provide an update on the available and upcoming treatment options for IBS-D in Canada, with reference to the recently updated Canadian IBS consensus guidelines. Initial treatment approaches include lifestyle modifications, dietary modifications, and non-prescription therapies such as peppermint oil. While some medications such as tricyclic antidepressants are also used to treat IBS-D symptoms, eluxadoline and rifaximin are the only two pharmacological therapies approved for the treatment of IBS-D in Canada. Key clinical trial data for the currently available pharmacological options are presented to provide an overview of the efficacy and safety of these agents |
| Related Links | https://academic.oup.com/jcag/article-pdf/3/6/e37/34443066/gwz034.pdf |
| Ending Page | e48 |
| Starting Page | e37 |
| File Format | |
| ISSN | 25152084 |
| e-ISSN | 25152092 |
| DOI | 10.1093/jcag/gwz034 |
| Journal | Journal of the Canadian Association of Gastroenterology |
| Issue Number | 6 |
| Volume Number | 3 |
| Language | English |
| Publisher | Oxford Academic |
| Publisher Date | 2020-11-20 |
| Access Restriction | Open |
| Subject Keyword | Clinical Medicine Gastroenterology Medicine and Health Diarrhea Irritable Bowel Syndrome Irritable Bowel Syndrome with Diarrhea Eluxadoline Rifaximin Abdominal Pain Safety Diarrhea-predominant Irritable Bowel Syndrome Management Treatment |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health Informatics |
