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Bacterial pneumonia coinfection and antimicrobial therapy duration in SARS-CoV-2 (COVID-19) infection
| Content Provider | Oxford Academic |
|---|---|
| Author | Townsend, Liam Hughes, Gerry Kerr, Colm Kelly, Mary O’Connor, Roisin Sweeney, Eileen Doyle, Catriona O’Riordan, Ruth Martin-Loeches, Ignacio Bergin, Colm Bannan, Ciaran |
| Copyright Year | 2020 |
| Abstract | Background: Bacterial respiratory coinfection in the setting of SARS-CoV-2 infection remains poorly described. A description of coinfection and antimicrobial usage is needed to guide ongoing antimicrobial stewardship.ObjectivesTo assess the rate of empirical antimicrobial treatment in COVID-19 cases, assess the rate and methods of microbiological sampling, assess the rate of bacterial respiratory coinfections and evaluate the factors associated with antimicrobial therapy in this cohort.MethodsInpatients with positive SARS-CoV-2 PCR were recruited. Antibiotic prescription, choice and duration were recorded. Taking of microbiological samples (sputum culture, blood culture, urinary antigens) and culture positivity rate was also recorded. Linear regression was performed to determine factors associated with prolonged antimicrobial administration.ResultsA total of 117 patients were recruited; 84 (72%) were prescribed antimicrobial therapy for lower respiratory tract infections. Respiratory pathogens were identified in seven (6%) patients. The median duration of antimicrobial therapy was 7 days. C-reactive protein level, oxygen requirement and positive cultures were associated with prolonged duration of therapy. ConclusionsThe rate of bacterial coinfection in SARS-CoV-2 is low. Despite this, prolonged courses of antimicrobial therapy were prescribed in our cohort. We recommend active antimicrobial stewardship in COVID-19 cases to ensure appropriate antimicrobial prescribing. |
| Related Links | https://academic.oup.com/jacamr/article-pdf/2/3/dlaa071/38269619/dlaa071.pdf |
| File Format | |
| e-ISSN | 26321823 |
| DOI | 10.1093/jacamr/dlaa071 |
| Journal | JAC-Antimicrobial Resistance |
| Issue Number | 3 |
| Volume Number | 2 |
| Language | English |
| Publisher | Oxford Academic |
| Publisher Date | 2020-09-01 |
| Access Restriction | Open |
| Subject Keyword | Clinical Medicine Clinical Pharmacology and Therapeutics Infectious Diseases Medical Microbiology and Virology Medicine and Health Pathology Antimicrobials Coinfection Infections Duration of Treatment Sars-cov-2 Covid-19 Bacterial Pneumonia Lower Respiratory Tract Infections Polymerase Chain Reaction Antigens Blood Culture Urinary Tract Inpatients Antibiotics Pathogenic Organism Antimicrobial Stewardship |
| Content Type | Text |
| Resource Type | Article |
| Subject | Microbiology (medical) Immunology and Allergy Microbiology Immunology Infectious Diseases |
