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Effects of switching from oral administration to intravenous injection of l-carnitine on lipid metabolism in hemodialysis patients
| Content Provider | Oxford Academic |
|---|---|
| Author | Fukami, Kei Yamagishi, Sho-ichi Sakai, Kazuko Nasu, Makoto Okuda, Seiya |
| Copyright Year | 2014 |
| Abstract | Background: Carnitine deficiency may contribute to cardiovascular disease (CVD) in patients with hemodialysis (HD). Dyslipidemia plays a role in CVD and its prevalence is also high in HD patients. We examined here the effects of switching from oral administration (PO) to intravenous (IV) injection of l-carnitine on lipid metabolism in patients with HD.MethodsNine HD patients who had received l-carnitine orally (900 mg/day) for 1 year were enrolled in this study. We examined whether lipid parameters were improved by switching to IV injection therapy of 1000 mg l-carnitine.ResultsIV injection of l-carnitine for 1 week significantly increased total, free and acyl carnitine levels both before and after HD. Switching to IV injection therapy for 1 and 4 weeks decreased serum free fatty acid (FFA) (322 ± 104 versus 261 ± 124 µmol/L) and increased high-density lipoprotein-cholesterol levels (1.46 ± 0.49 versus 1.63 ± 0.62 mmol/L), respectively. Change in FFA values from the baseline (ΔFFA) was positively correlated with the Δacyl/free carnitine ratio (r2 = 0.553, P = 0.022).ConclusionThis study demonstrated that switching to IV l-carnitine therapy from oral supplementation improved lipid profiles, thus supporting the clinical utility of IV administration of l-carnitine for the treatment of patients on HD. |
| Related Links | https://academic.oup.com/ckj/article-pdf/7/5/470/904549/sfu082.pdf |
| Ending Page | 474 |
| Starting Page | 470 |
| File Format | |
| ISSN | 20488505 |
| e-ISSN | 20488513 |
| DOI | 10.1093/ckj/sfu082 |
| Journal | Clinical Kidney Journal |
| Issue Number | 5 |
| Volume Number | 7 |
| Language | English |
| Publisher | Oxford Academic |
| Publisher Date | 2014-10-01 |
| Access Restriction | Open |
| Subject Keyword | Clinical Medicine Medicine and Health Nephrology Carnitine Intravenous Injections Cardiovascular Diseases Free Fatty Acid Hdl-cholesterol Hemodialysis L-carnitine |
| Content Type | Text |
| Resource Type | Article |
| Subject | Transplantation Nephrology |
