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Proteinuria in COVID-19
| Content Provider | Oxford Academic |
|---|---|
| Author | Mohamed, Muner M B Velez, Juan Carlos Q |
| Copyright Year | 2021 |
| Abstract | Upper respiratory and pulmonary diseases are the primary manifestations of coronavirus disease 2019 (COVID-19). However, kidney involvement has also been recognized and extensively described. A large percentage of affected patients present with acute kidney injury (AKI). However, specific phenotypic aspects of AKI or other renal manifestations of COVID-19 remain sparsely characterized. Many reports indicate that proteinuria can be detected in AKI associated with COVID-19 (CoV-AKI) despite CoV-AKI being largely described as a form of acute tubular injury. On the other hand, individuals of African ancestry with the high-risk APOL1 genotype are uniquely at risk of developing collapsing glomerulopathy when they are infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the entity now known as COVID-19-associated nephropathy (COVAN). Patients with COVAN typically present with nephrotic-range proteinuria. The exact incidence of proteinuria in COVID-19 is unclear due to heterogeneity in the frequency with which proteinuria has been assessed in cases of COVID-19, as well as methodological differences in the way proteinuria is measured and/or reported. In this review we discuss the current evidence of proteinuria as a manifestation of COVID-19 and elaborate on potential pathophysiological mechanisms associated with it. |
| Related Links | https://academic.oup.com/ckj/article-pdf/14/Supplement_1/i40/36737912/sfab036.pdf |
| Ending Page | i47 |
| Starting Page | i40 |
| File Format | |
| ISSN | 20488505 |
| e-ISSN | 20488513 |
| DOI | 10.1093/ckj/sfab036 |
| Journal | Clinical Kidney Journal |
| Issue Number | Suppl_1 |
| Volume Number | 14 |
| Language | English |
| Publisher | Oxford Academic |
| Publisher Date | 2021-03-26 |
| Access Restriction | Open |
| Subject Keyword | Clinical Medicine Medicine and Health Nephrology Nephrotic Syndrome Proteinuria Covid-19 Sars-cov-2 Kidney Aki Albuminuria Nephrotic Protein-to-creatinine |
| Content Type | Text |
| Resource Type | Article |
| Subject | Transplantation Nephrology |
