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[18F]-AV-1451 binding in the substantia nigra as a marker of neuromelanin in Lewy body diseases
| Content Provider | Oxford Academic |
|---|---|
| Author | Mak, Elijah Kouli, Antonina Holland, Negin Nicastro, Nicolas Savulich, George Surendranathan, Ajenthan Malpetti, Maura Manavaki, Roido Hong, Young T Fryer, Tim D Aigbirhio, Franklin Rowe, James B O’Brien, John T Williams-Gray, Caroline H |
| Copyright Year | 2021 |
| Abstract | While [18F]-AV-1451 was developed as a PET radiotracer with high affinity for hyperphosphorylated tau, it has been proposed that loss of 'off-target' [18F]-AV-1451 binding to neuromelanin in the substantia nigra could be a surrogate marker of Lewy body diseases. [18F]-AV-1451 binding was measured in the substantia nigra of patients with Parkinson's disease (n = 35), dementia with Lewy bodies (n = 10) and separate control groups (n = 37; n = 14). Associations with motor symptoms, cognition and disease duration were evaluated using linear regression models. The dementia with Lewy bodies group had significantly reduced substantia nigra [18F]-AV-1451 binding compared to controls after adjusting for age (P < 0.05). However, there were no significant differences in substantia nigra [18F]-AV-1451 binding between Parkinson's disease and controls. Substantia nigra [18F]-AV-1451 binding was not associated with age, disease duration, Movement Disorders Society—Unified Parkinson's Disease Rating Scale and cognitive scores in dementia with Lewy bodies and Parkinson's disease groups. Despite the reduction of substantia nigra [18F]-AV-1451 binding in dementia with Lewy bodies, these findings suggest that substantia nigra [18F]-AV-1451 binding has no value as a diagnostic marker in early Parkinson's disease. Further investigations in longitudinal cohorts are warranted. |
| Related Links | https://academic.oup.com/braincomms/article-pdf/3/3/fcab177/40216039/fcab177.pdf |
| File Format | |
| e-ISSN | 26321297 |
| DOI | 10.1093/braincomms/fcab177 |
| Journal | Brain Communications |
| Issue Number | 3 |
| Volume Number | 3 |
| Language | English |
| Publisher | Oxford Academic |
| Publisher Date | 2021-07-01 |
| Access Restriction | Open |
| Subject Keyword | Clinical Medicine Medicine and Health Neurology Neuroscience Science and Mathematics Lewy Bodies Substantia Nigra Parkinson Disease Tau Proteins Lewy Body Disease Illness Length Unified Parkinson's Disease Rating Scale Dementia Tau Neuromelanin Parkinson's Disease |
| Content Type | Text |
| Resource Type | Article |
| Subject | Psychiatry and Mental Health Neurology Cellular and Molecular Neuroscience Biological Psychiatry |
