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Neurological component in coronaviruses induced disease: Systematic review of SARS‐CoV, MERS‐CoV, AND SARS‐CoV‐ 2
| Content Provider | Open Science Framework (OSF) |
|---|---|
| Author | Carlo Lastarria Brenda Nadia Chino Vilca Tessy Tairo Victor Munive Jonathan Zegarra-Valdivia |
| Abstract | BACKGROUND: The COVID-19 was declared like the pandemic of the 21st century and has caused more than 45 thousand deaths worldwide. The abrupt onset of SARS-CoV-2 demonstrated the potential infection, morbidity, and lethality of zoonotic viruses and the human-to-human transmission. The fever, cough, and fatigue are the most common symptoms of the disease and include too, acute respiratory distress syndrome, shock, acute cardiac injury, and acute renal injury between others signs in severe illness. Considered the previous work with human coronavirus and other zoonotic infections, the neuroinvasive propensity has been demonstrated as a common feature of coronaviruses, especially between SARS-CoV and MERS-CoV. OBJECTIVE: In the current review, we analyzed the possible neurological component in coronaviruses infections and detail neurologic syndrome related to COVID-19 disease. We review too, transmission mechanism and CNS pathology related to another virus with similar structures like SARS-CoV and MERS-CoV. METHODS: An exhaustive search of different original articles, clinical, experimental, and review studies were performed in MEDLINE / PubMed, Scopus, and Web of Science databases. We selected 92 articles that have been published in journals or in preprint according to the search words and the inclusion and exclusion criteria. RESULTS: COVID-19 patients may present neurological symptoms such as headache, impair mental state, confusion dizziness, nausea and vomiting, anosmia/hyposmia, dysgeusia/hypogeusia as initial symptoms. To a more severe manifestation such as seizures or coma. The showed neurologic signs are clinical symptoms similar to those reported for SARS‐CoV and MERS‐CoV. Considering that SARS-CoV and MERS-CoV have a similar structure is possible that the virus shares comparable neurological symptoms and that progression would be similar. The coronaviruses are linked to CNS dysfunction and were indicated as Multiple sclerosis, encephalitis or meningitis as the probable cause. |
| Alternate Webpage(s) | http://dx.doi.org/10.31219/OSF.IO/2FQTZ |
| Publisher | OSF |
| Publisher Date | 2020-04-07 |
| Access Restriction | Open |
| Subject Keyword | sars-cov covid-19 central nervous system mers-cov sars-cov-2 coronavirus review |
| Content Type | Text |
| Resource Type | Preprint |
