NDLI: Sipuleucel-T for therapy of asymptomatic or minimally symptomatic, castrate-refractory prostate cancer: an update and perspective among other treatments

Content Provider	Open Access Library (OALib)
Author	Gupta SG Carballido ES Fishman M.
Abstract	Shilpa Gupta, Estrella Carballido, Mayer FishmanMoffitt Cancer Center and Research Institute, Tampa, FL, USAAbstract: Sipuleucel-T is an autologous cell immunotherapy for castrate-refractory prostate cancer, with US Food and Drug Administration (FDA) approval in asymptomatic or minimally symptomatic prostate cancer. In this review we address the background of prostate cancer incidence and other available therapy onto which sipuleucel-T treatment has been added, with discussion of hormone-therapy, chemotherapy, and other investigational immunotherapies. The sipuleucel-T manufacturing process, toxicity and clinical benefit are reviewed, along with an examination of the issue of clinical benefit to survival, independent of apparent changes of prostate-specific antigen (PSA) levels. Sipuleucel-T therapy is appraised from clinician, patient and immunotherapeutic perspectives, with reference to the clinical data from the pivotal trial, the mechanism of action, and the treatment process.Keywords: sipuleucel-T, immunotherapy, vaccine, immunotherapy, dendritic cells
ISSN	11786930
Journal	OncoTargets and Therapy
Publisher	Dove Medical Press
Publisher Date	2011-01-01
Access Restriction	Open
Content Type	Text
Resource Type	Article
Subject	Pharmacology (medical) Oncology

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