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Hepatitis B-related events in autologous hematopoietic stem cell transplantation recipients
| Content Provider | Open Access Library (OALib) |
|---|---|
| Author | ？zcan ？eneli Zübeyde Nur ？zkurt Kadir Acar Seyyal Rota ？ahika Zeynep Ak？ Zeynep Arzu Ye？in Münci Ya？c？ Seren ？zenirler Gülsan Türk？z Sucak |
| Abstract | AIM: To investigate the frequency of occult hepatitis B, the clinical course of hepatitis B virus (HBV) reactivation and reverse seroconversion and associated risk factors in autologous hematopoietic stem cell transplantation (HSCT) recipients.METHODS: This study was conducted in 90 patients undergoing autologous HSCT. Occult HBV infection was investigated by HBV-DNA analysis prior to transplantation, while HBV serology and liver function tests were screened prior to and serially after transplantation. HBV-related events including reverse seroconversion and reactivation were recorded in all patients.RESULTS: None of the patients had occult HBV prior to transplantation. Six (6.7%) patients were positive for HBV surface antigen (HBsAg) prior to transplantation and received lamivudine prophylaxis; they did not develop HBV reactivation after transplantation. Clinical HBV infection emerged in three patients after transplantation who had negative HBV-DNA prior to HSCT. Two of these three patients had HBV reactivation while one patient developed acute hepatitis B. Three patients had anti-HBc as the sole hepatitis B-related antibody prior to transplantation, two of whom developed hepatitis B reactivation while none of the patients with antibody to HBV surface antigen (anti-HBs) did so. The 14 anti-HBs- and/or anti-HBc-positive patients among the 90 HSCT recipients experienced either persistent (8 patients) or transient (6 patients) disappearance of anti-HBs and/or anti-HBc. HBsAg seroconversion and clinical hepatitis did not develop in these patients. Female gender and multiple myeloma emerged as risk factors for loss of antibody in regression analysis (P <0.05).CONCLUSION: Anti-HBc as the sole HBV marker seems to be a risk factor for reactivation after autologous HSCT. Lamivudine prophylaxis in HbsAg-positive patients continues to be effective. |
| ISSN | 10079327 |
| Journal | World Journal of Gastroenterology |
| Publisher | Baishideng Publishing Group Co. Limited |
| Publisher Date | 2010-01-01 |
| Access Restriction | Open |
| Subject Keyword | Multiple myeloma Autologous stem cell transplantation Hepatitis B reactivation Occult hepatitis Lymphoma |
| Content Type | Text |
| Resource Type | Article |
| Subject | Gastroenterology |
