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A Single Immunization with Soluble Recombinant Trimeric Hemagglutinin Protects Chickens against Highly Pathogenic Avian Influenza Virus H5N1
| Content Provider | Open Access Library (OALib) |
|---|---|
| Author | Lisette A. H. M. Cornelissen Robert P. de Vries Els A. de Boer-Luijtze Alan Rigter Peter J. M. Rottier Cornelis A. M. de Haan |
| Abstract | The highly pathogenic avian influenza (HPAI) virus H5N1 causes multi-organ disease and death in poultry, resulting in significant economic losses in the poultry industry. In addition, it poses a major public health threat as it can be transmitted directly from infected poultry to humans with very high (60%) mortality rate. Effective vaccination against HPAI H5N1 would protect commercial poultry and would thus provide an important control measure by reducing the likelihood of bird-to-bird and bird-to-human transmission. |
| ISSN | 19326203 |
| Journal | PLOS ONE |
| DOI | 10.1371/journal.pone.0010645 |
| Publisher | Public Library of Science (PLoS) |
| Publisher Date | 2012-01-01 |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
| Subject | Multidisciplinary |
