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Effects of Aging on ACTH-Stimulated Steroidogenesis in Subcellular Fractions from Rat Adrenal Glands
| Content Provider | University of North Texas |
|---|---|
| Author | Sawada, Tadao |
| Description | Young, middle-aged and old rat adrenal gland steroidogenesis was measured in isolated, superfused glands and in their subcellular fractions before and after adrenocorticotropic hormone treatment. In the latter experiment, five corticosteroids were extracted from six different subcellular fractions. Superfused glands initially produced relatively high glucocorticoid levels; thereafter, production decayed asymptotically. Steroidogenesis by young and middle-aged glands was maintained at least 1.5 to 2.5 hours before it decayed; old glands were 50% less active than younger ones and production decayed within one hour. High cholesterol and progesterone levels in certain old gland fractions were associated with correspondingly reduced 11-deoxycorticosterone and corticosterone. It is suggested that synthesis of these glucocorticoids from their accumulating precursors weakens with age. |
| File Format | |
| Archival Resource Key | ark:/67531/metadc663513 |
| Language | English |
| Publisher | North Texas State University |
| Publisher Date | 2017-01-03 |
| Publisher Place | Denton, Texas |
| Access Restriction | Open |
| Subject Keyword | steroid hormones endocrine glands |
| Content Type | Text |
| Resource Type | Thesis |
