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Multigene Profiling of Circulating Tumor Cells (CTCs) for Prognostic Assessment in Treatment-Naïve Metastatic Hormone-Sensitive Prostate Cancer (mHSPC)
| Content Provider | MDPI |
|---|---|
| Author | Reichert, Zachery R. Kasputis, Tadas Nallandhighal, Srinivas Abusamra, Sophia M. Kasputis, Amy Haruray, Saloni Wang, Yugang Williams, Shamara Singhal, Udit Alva, Ajjai Cackowski, Frank C. Caram, Megan E. V. Palmbos, Phillip L. Yentz, Sarah E. Smith, David C. Alumkal, Joshi J. Morgan, Todd M. |
| Copyright Year | 2021 |
| Description | The substantial biological heterogeneity of metastatic prostate cancer has hindered the development of personalized therapeutic approaches. Therefore, it is difficult to predict the course of metastatic hormone-sensitive prostate cancer (mHSPC), with some men remaining on first-line androgen deprivation therapy (ADT) for several years while others progress more rapidly. Improving our ability to risk-stratify patients would allow for the optimization of systemic therapies and support the development of stratified prospective clinical trials focused on patients likely to have the greatest potential benefit. Here, we applied a liquid biopsy approach to identify clinically relevant, blood-based prognostic biomarkers in patients with mHSPC. Gene expression indicating the presence of CTCs was greater in CHAARTED high-volume (HV) patients (52% $CTC_{high}$) than in low-volume (LV) patients (23% $CTC_{high}$; * p = 0.03). HV disease (p = 0.005, q = 0.033) and CTC presence at baseline prior to treatment initiation (p = 0.008, q = 0.033) were found to be independently associated with the risk of nonresponse at 7 months. The pooled gene expression from CTCs of pre-ADT samples found AR, DSG2, KLK3, MDK, and PCA3 as genes predictive of nonresponse. These observations support the utility of liquid biomarker approaches to identify patients with poor initial response. This approach could facilitate more precise treatment intensification in the highest risk patients. |
| Starting Page | 4 |
| e-ISSN | 14220067 |
| DOI | 10.3390/ijms23010004 |
| Journal | International Journal of Molecular Sciences |
| Issue Number | 1 |
| Volume Number | 23 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-12-21 |
| Access Restriction | Open |
| Subject Keyword | International Journal of Molecular Sciences Oncology Urology and Nephrology Prostate Cancer Circulating Tumor Cells Ctcs Metastatic Hormone-sensitive Castration-sensitive Prognostic Gene Expression |
| Content Type | Text |
| Resource Type | Article |
