NDLI: Pharmacological and Parenteral Nutrition-Based Interventions in Microvillus Inclusion Disease

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Pharmacological and Parenteral Nutrition-Based Interventions in Microvillus Inclusion Disease

Content Provider	MDPI
Author	Leng, Changsen Rings, Edmond H. H. M. Wildt, Saskia N. De Ijzendoorn, Sven C. D. Van
Copyright Year	2020
Description	Microvillus inclusion disease (MVID) is a rare inherited and invariably fatal enteropathy, characterized by severe intractable secretory diarrhea and nutrient malabsorption. No cure exists, and patients typically die during infancy because of treatment-related complications. The need for alternative treatment strategies is evident. Several pharmacological interventions with variable successes have been tried and reported for individual patients as part of their clinical care. Unfortunately, these interventions and their outcomes have remained hidden in case reports and have not been reviewed. Further, recent advances regarding MVID pathogenesis have shed new light on the outcomes of these pharmacological interventions and offer suggestions for future clinical research and trials. Hence, an inventory of reported pharmacological interventions in MVID, their rationales and outcomes, and a discussion of these in the light of current knowledge is opportune. Together with a discussion on MVID-specific pharmacokinetic, -dynamic, and -genetic concerns that pose unique challenges regarding pharmacological strategies, we envision that this paper will aid researchers and clinicians in their efforts to develop pharmacological interventions to combat this devastating disease.
Starting Page	22
e-ISSN	20770383
DOI	10.3390/jcm10010022
Journal	Journal of clinical medicine
Issue Number	1
Volume Number	10
Language	English
Publisher	MDPI
Publisher Date	2020-12-23
Access Restriction	Open
Subject Keyword	Journal of clinical medicine Journal of Clinical Medicine Mycology Pharmacology and Pharmacy Microvillus Inclusion Disease Myo5b Myosin Vb Congenital Diarrheal Disorder Malabsorption
Content Type	Text
Resource Type	Article

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