NDLI: Study of Cytotoxic and Photodynamic Activities of Dyads Composed of a Zinc Phthalocyanine Appended to an Organotin

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Study of Cytotoxic and Photodynamic Activities of Dyads Composed of a Zinc Phthalocyanine Appended to an Organotin

Content Provider	MDPI
Author	Toubia, Isabelle Nguyen, Christophe Diring, Stéphane Pays, Marine Mattana, Elodie Arnoux, Philippe Frochot, Céline Gary-Bobo, Magali Kobeissi, Marwan Odobel, Fabrice
Copyright Year	2021
Description	The combination of photodynamic therapy and chemotherapy is a promising strategy to enhance cancer therapeutic efficacy and reduce drug resistance. In this study two zinc(II) phthalocyanine-tin(IV) conjugates linked by a triethylene glycol chain were synthesized and characterized. In these complexes, the zinc(II) phthalocyanine was used as a potential photosensitizer for PDT and the tin complex was selected as cytostatic moiety. The two dyads composed of zinc(II) phthalocyanine and tin complexes exhibited high cytotoxicity, in absence of light stimulation, against MCF-7 human breast cancer cells with low LC50 values in the range of 0.016–0.453 µM. In addition, these complexes showed superior cytotoxicity than their mixture of equimolar component, accompanied with a higher activity towards cancer cells compared to human healthy fibroblasts. However, under irradiation of the zinc phthalocyanine unit (at 650 nm) no photodynamic activity could be detected, due to the most likely quenching of zinc(II) phthalocyanine singlet excited state by the nearby tin complex according to a photoinduced electron transfer process. This study demonstrates the potential of heterometallic anticancer chemotherapeutics composed of a zinc phthalocyanine and tin complex, and it highlights that the development of such conjugates requires that the sensitizer preserves its photophysical properties and in particular its singlet oxygen sensitization ability in the conjugate in order to combine the PDT activity with the cytotoxicity of the anticancer drug.
Starting Page	413
e-ISSN	14248247
DOI	10.3390/ph14050413
Journal	Pharmaceuticals
Issue Number	5
Volume Number	14
Language	English
Publisher	MDPI
Publisher Date	2021-04-28
Access Restriction	Open
Subject Keyword	Pharmaceuticals Inorganic Chemistry Photodynamic Therapy Chemotherapy Zinc (ii) Phthalocyanine Tin Complex
Content Type	Text
Resource Type	Article

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