NDLI: Green Synthesis of Silver Nanoparticles Using Populi gemmae Extract: Preparation, Physicochemical Characterization, Antimicrobial Potential and In Vitro Antiproliferative Assessment

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Green Synthesis of Silver Nanoparticles Using Populi gemmae Extract: Preparation, Physicochemical Characterization, Antimicrobial Potential and In Vitro Antiproliferative Assessment

Content Provider	MDPI
Author	Elena-Alina, Moacă Kis, Brigitta Tudoran, Lucian Barbu Muntean, Delia Magyari-Pavel, Ioana Zinuca Minda, Daliana Ionela Lombrea, Adelina Diaconeasa, Zorita Dehelean, Cristina Adriana Dinu, Ștefania Danciu, Corina
Copyright Year	2022
Description	Green route is an economic, facile and eco-friendly method, employed for the synthesis of various types of nanoparticles, having it as a starting point biological entity, especially as a plant extract. The present study aims to obtain silver nanoparticles (AgNPs) starting from an ethanolic extract of Populi gemmae (Pg), by adjusting the reaction parameters. The morphological and structural characterization exhibited that both the reaction temperature and the concentration of metal salt, contributes to the obtaining of Pg-AgNPs with adjustable size and shape. The newly synthesized nanoparticles exhibited a good antibacterial activity on Gram-positive bacteria as well as antifungal activity. The in vitro antiproliferative activity of Pg-AgNPs was assessed on two different cancer cell lines (breast cancer cells—MCF7 and lung carcinoma epithelial cells—A549). Results have shown that the green-synthetized Pg-AgNPs_S2 (obtained at 60 °C, using $AgNO_{3}$ of 5 M) induced a substantial decrease in tumor cell viability in a dose-dependent manner with an $IC_{50}$ ranging from 5.03 to 5.07 µg/mL on A549 cell line and 3.24 to 4.93 µg/mL on MCF7 cell line.
Starting Page	5006
e-ISSN	19961944
DOI	10.3390/ma15145006
Journal	Materials
Issue Number	14
Volume Number	15
Language	English
Publisher	MDPI
Publisher Date	2022-07-19
Access Restriction	Open
Subject Keyword	Materials Toxicology Green Synthesis Populus Nigra L. Silver Nanoparticles Antimicrobial Potential Antiproliferative Activity
Content Type	Text
Resource Type	Article

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