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Reducing the Pill Burden: Immunosuppressant Adherence and Safety after Conversion from a Twice-Daily (IR-Tac) to a Novel Once-Daily (LCP-Tac) Tacrolimus Formulation in 161 Liver Transplant Patients
| Content Provider | MDPI |
|---|---|
| Author | Robert, Öllinger Wenzel, Schöning Maurer, Max M. Ibach, Marius Plewe, Julius Winter, Axel Ritschl, Paul Globke, Brigitta Lurje, Georg Pratschke, Johann Eurich, Dennis |
| Copyright Year | 2022 |
| Description | Non-adherence to immunosuppressant therapy reduces long-term graft and patient survival after solid organ transplantation. The objective of this 24-month prospective study was to determine adherence, efficacy and safety after conversion of stable liver transplant (LT) recipients from a standard twice-daily immediate release Tacrolimus (IR-Tac) to a novel once-daily life cycle pharma Tacrolimus (LCP-Tac) formulation. We converted a total of 161 LT patients at baseline, collecting Tacrolimus trough levels, laboratories, physical examination data and the $BAASIS^{©}$ questionnaire for self-reported adherence to immunosuppression at regular intervals. With 134 participants completing the study period (17% dropouts), the overall adherence to the $BAASIS^{©}$ increased by 57% until month 24 compared to baseline (51% vs. 80%). Patients who required only a morning dose of their concomitant medications reported the largest improvement in adherence after conversion. The intra-patient variability (IPV) of consecutive Tacrolimus trough levels after conversion did not change significantly compared to pre-conversion levels. Despite reducing the daily dose by 30% at baseline as recommended by the manufacturer, Tac-trough levels remained stable, reflected by an increase in the concentration-dose (C/D) ratio. No episodes of graft rejection or loss occurred. Our data suggest that the use of LCP-Tac in liver transplant patients is safe and can increase adherence to immunosuppression compared to conventional IR-Tac. |
| Starting Page | 272 |
| e-ISSN | 22279059 |
| DOI | 10.3390/biomedicines10020272 |
| Journal | Biomedicines |
| Issue Number | 2 |
| Volume Number | 10 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-01-26 |
| Access Restriction | Open |
| Subject Keyword | Biomedicines Transplantation Immunosuppressant Adherence Immunosuppressant Efficacy Tacrolimus Liver Transplantation |
| Content Type | Text |
| Resource Type | Article |
