Loading...
Please wait, while we are loading the content...
Similar Documents
Human Coronavirus Spike Protein Based Multi-Epitope Vaccine against COVID-19 and Potential Future Zoonotic Coronaviruses by Using Immunoinformatic Approaches
| Content Provider | MDPI |
|---|---|
| Author | Baloch, Zulqarnain Ikram, Aqsa Shamim, Saba Obaid, Ayesha Awan, Faryal Mehwish Naz, Anam Rauff, Bisma Gilani, Khadija Qureshi, Javed Anver |
| Copyright Year | 2022 |
| Description | Zoonotic coronaviruses (CoV) have emerged twice and have caused severe respiratory diseases in humans. Due to the frequent outbreaks of different human coronaviruses (HCoVs), the development of a pan-HCoV vaccine is of great importance. Various conserved epitopes shared by HCoVs are reported to induce cross-reactive T-cell responses. Therefore, this study aimed to design a multi-epitope vaccine, targeting the HCoV spike protein. Genetic analysis revealed that the spike region is highly conserved among SARS-CoV-2, bat SL-CoV, and SARS-CoV. By employing the immunoinformatic approach, we prioritized 20 MHC I and 10 MHCII conserved epitopes to design a multi-epitope vaccine. This vaccine candidate is anticipated to strongly elicit both humoral and cell-mediated immune responses. These results warrant further development of this vaccine into real-world application. |
| Starting Page | 1150 |
| e-ISSN | 2076393X |
| DOI | 10.3390/vaccines10071150 |
| Journal | Vaccines |
| Issue Number | 7 |
| Volume Number | 10 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-07-19 |
| Access Restriction | Open |
| Subject Keyword | Vaccines Infectious Diseases Sars-cov-2 Bat Sl-cov and Sars-cov Immunoinformatics Vaccine |
| Content Type | Text |
| Resource Type | Article |
