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West Mexico Berries Modulate α-Amylase, α-Glucosidase and Pancreatic Lipase Using In Vitro and In Silico Approaches
| Content Provider | MDPI |
|---|---|
| Author | David, Fonseca Hernández Virgen-Carrillo, Carmen Alejandrina Miramontes, Elia Herminia Valdés Luna-Vital, Diego A. Mojica, Luis |
| Copyright Year | 2022 |
| Description | The objective was to evaluate the antioxidant and biological potential of eight freeze-dried berry varieties of southern Jalisco using in silico and in vitro approaches. Fourteen tentative phenolic compounds were identified in berries by ESI-QToF, including anthocyanins, phenolic acids, flavanols and flavonols. In silico assays of phytochemicals in the berry inhibiting enzymes related to obesity and diabetes showed predicted binding energy interactions (ranging from −5.4 to −9.3 kcal/mol). Among the cultivars, antioxidant potential for DPPH $IC_{50}$ ranged from 1.27 to 3.40 mg/mL, ABTS $IC_{50}$ from 2.26 to 7.32 mg/mL and nitric oxide (NO) inhibition $IC_{50}$ from 4.26 to 11.07 mg/mL. The potential to inhibit α-amylase $IC_{50}$ ranged from 4.02 to 7.66 mg/mL, α-glucosidase $IC_{50}$ from 0.27 to 4.09 mg/mL, lipase $IC_{50}$ from 1.30 to 4.82 mg/mL and DPP-IV $IC_{50}$ from 1.36 to 3.31 mg/mL. Blackberry cultivars from the southern Jalisco region showed outstanding biological potential compared to other evaluated berries and could be used in the formulation of functional foods in the prevention of noncommunicable diseases. |
| Starting Page | 1081 |
| e-ISSN | 14248247 |
| DOI | 10.3390/ph15091081 |
| Journal | Pharmaceuticals |
| Issue Number | 9 |
| Volume Number | 15 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-08-30 |
| Access Restriction | Open |
| Subject Keyword | Pharmaceuticals Food Science and Technology Raspberry Blueberry Blackberry Freeze-drying Antioxidant Potential Α-amylase Α-glucosidase |
| Content Type | Text |
| Resource Type | Article |
