NDLI: Possible Association between Bladder Wall Morphological Changes on Computed Tomography and Bladder-Centered Interstitial Cystitis/Bladder Pain Syndrome

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Possible Association between Bladder Wall Morphological Changes on Computed Tomography and Bladder-Centered Interstitial Cystitis/Bladder Pain Syndrome

Content Provider	MDPI
Author	Jhang, Jia-Fong Hsu, Yung-Hsiang Ho, Han-Chen Jiang, Yuan-Hong Lee, Cheng-Ling Yu, Wan-Ru Kuo, Hann-Chorng
Copyright Year	2021
Description	This study aimed to evaluate the clinical significance of urinary bladder wall thickening on computed tomography (CT) among patients with interstitial cystitis/bladder pain syndrome (IC/BPS). Patients with IC/BPS were prospectively enrolled and classified into three groups according to bladder CT finding: smooth bladder wall, focal bladder thickening, and diffuse bladder thickening. Among the 100 patients with IC/BPS, 49, 36, and 15 had smooth bladder wall, focal bladder thickening, and diffuse bladder thickening on CT, respectively. Patients with Hunner’s lesion showed a higher proportion of diffuse and focal bladder thickening compared to those without the same (p < 0.001). Patients with diffuse bladder thickening displayed smaller first sensation of filling, cystometric bladder capacity, and voided volume compared to the rest (all p < 0.001). Patients with focal and diffuse thickening had a higher proportion of inflammatory cell infiltration, uroepithelial cell denudation, and granulation tissue compared to those with smooth bladder wall (p = 0.045, 0.002, and 0.005, respectively). Bladder wall thickening on CT was correlated with clinical phenotypes of IC/BPS, including histopathological findings. Focal or diffuse bladder wall thickening on CT might indicate the presence of chronic bladder wall inflammation and fibrosis and could be used to differentiate bladder-centered IC/BPS.
Starting Page	1306
e-ISSN	22279059
DOI	10.3390/biomedicines9101306
Journal	Biomedicines
Issue Number	10
Volume Number	9
Language	English
Publisher	MDPI
Publisher Date	2021-09-24
Access Restriction	Open
Subject Keyword	Biomedicines Urology and Nephrology Bladder Histopathology Chronic Inflammation Cystitis
Content Type	Text
Resource Type	Article

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