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Protein-, (Poly)peptide-, and Amino Acid-Based Nanostructures Prepared via Polymerization-Induced Self-Assembly
| Content Provider | MDPI |
|---|---|
| Author | Varlas, Spyridon Maitland, Georgia Derry, Matthew |
| Copyright Year | 2021 |
| Description | Proteins and peptides, built from precisely defined amino acid sequences, are an important class of biomolecules that play a vital role in most biological functions. Preparation of nanostructures through functionalization of natural, hydrophilic proteins/peptides with synthetic polymers or upon self-assembly of all-synthetic amphiphilic copolypept(o)ides and amino acid-containing polymers enables access to novel protein-mimicking biomaterials with superior physicochemical properties and immense biorelevant scope. In recent years, polymerization-induced self-assembly (PISA) has been established as an efficient and versatile alternative method to existing self-assembly procedures for the reproducible development of block copolymer nano-objects in situ at high concentrations and, thus, provides an ideal platform for engineering protein-inspired nanomaterials. In this review article, the different strategies employed for direct construction of protein-, (poly)peptide-, and amino acid-based nanostructures via PISA are described with particular focus on the characteristics of the developed block copolymer assemblies, as well as their utilization in various pharmaceutical and biomedical applications. |
| Starting Page | 2603 |
| e-ISSN | 20734360 |
| DOI | 10.3390/polym13162603 |
| Journal | Polymers |
| Issue Number | 16 |
| Volume Number | 13 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-08-05 |
| Access Restriction | Open |
| Subject Keyword | Polymers Biophysics Proteins Polypeptides Α-amino Acids Block Copolymers Polymerization-induced Self-assembly Protein–polymer Conjugates Nanostructures Biomaterials |
| Content Type | Text |
| Resource Type | Article |
