NDLI: Gold Nanoparticles Green-Synthesized by the S껚 japonica Leaf Extract and Screening of Anti-Inflammatory Activities on RAW 267.4 Macrophages

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Gold Nanoparticles Green-Synthesized by the S껚 japonica Leaf Extract and Screening of Anti-Inflammatory Activities on RAW 267.4 Macrophages

Content Provider	MDPI
Author	Kwak, Gi-Young Han, Yaxi Baik, Sul Kong, Byoung-Man Yang, Deok-Chun Kang, Se-Chan Sukweenadhi, Johan
Copyright Year	2022
Description	Biosynthesis of gold nanoparticles from medicinal plants has become a modern strategy in biomedical research based on their exclusive properties, including specific targeting, lower toxicity, and biocompatibility. In this study, gold nanoparticles, reduced by the S껚 japonica leaf extract, were promptly validated by UV–visible (UV–Vis) spectroscopy at 548 nm. No additional reducing agents were needed in this kind of a reduction reaction, which provided evidence of green synthesis. Dynamic light scattering (DLS), energy-dispersive X-ray spectroscopy (EDX), field-emission transmission electron microscopy (FE-TEM), selected area electron diffraction (SAED), and X-ray diffraction (XRD) analyses were used to illustrate the nanoscale characterization of S. japonica gold nanoparticles (Sj-AuNps). Furthermore, the cytotoxicity effect of Sj-AuNps against the RAW 264.7 cell line was determined by performing an MTT assay. We also investigated Sj-AuNps’ anti-inflammatory properties in LPS-induced murine macrophages. These nanoparticles reduced the generation of nitric oxide (NO) and prostaglandin E2 $(PGE_{2}$) and repressed the expression of the LPS-stimulated inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) genes. This study presents a significant biomedical application of S. japonica AuNps. The anti-inflammatory capabilities of Sj-AuNps underline their potential as possible options for suppressing inflammation-mediated diseases.
Starting Page	460
e-ISSN	20796412
DOI	10.3390/coatings12040460
Journal	Coatings
Issue Number	4
Volume Number	12
Language	English
Publisher	MDPI
Publisher Date	2022-03-28
Access Restriction	Open
Subject Keyword	Coatings Integrative and Complementary Medicine Anti-inflammatory Biosynthesis Gold Nanoparticles Suaeda Japonica
Content Type	Text
Resource Type	Article

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