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Salinomycin-Based Drug Delivery Systems: Overcoming the Hurdles in Cancer Therapy
| Content Provider | MDPI |
|---|---|
| Author | Cristina, Barbălată Ioan, Tomuță Tefas, Lucia Tefas, Cristian |
| Copyright Year | 2021 |
| Description | Cancer stem cells (CSCs) are reportedly responsible for the initiation and propagation of cancer. Since CSCs are highly resistant to conventional chemo- and radiotherapy, they are considered the main cause of cancer relapse and metastasis. Salinomycin (Sali), an anticoccidial polyether antibiotic, has emerged as a promising new candidate for cancer therapy, with selective cytotoxicity against CSCs in various malignancies. Nanotechnology provides an efficient means of delivering Sali to tumors in view of reducing collateral damage to healthy tissues and enhancing the therapeutic outcome. This review offers an insight into the most recent advances in cancer therapy using Sali-based nanocarriers. |
| Starting Page | 1120 |
| e-ISSN | 19994923 |
| DOI | 10.3390/pharmaceutics13081120 |
| Journal | Pharmaceutics |
| Issue Number | 8 |
| Volume Number | 13 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-07-22 |
| Access Restriction | Open |
| Subject Keyword | Pharmaceutics Oncology Salinomycin Nanoparticles Cancer Stem Cells Cancer Drug Delivery System Nanotechnology Nanosystems |
| Content Type | Text |
| Resource Type | Article |
