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Rare Chromone Derivatives from the Marine-Derived Penicillium citrinum with Anti-Cancer and Anti-Inflammatory Activities
| Content Provider | MDPI |
|---|---|
| Author | Chu, Yi-Cheng Chang, Chun-Hao Liao, Hsiang-Ruei Cheng, Ming-Jen Wu, Ming-Der Fu, Shu-Ling Chen, Jih-Jung |
| Copyright Year | 2021 |
| Description | Three new and rare chromone derivatives, epiremisporine C (1), epiremisporine D (2), and epiremisporine E (3), were isolated from marine-derived Penicillium citrinum, together with four known compounds, epiremisporine B (4), penicitrinone A (5), 8-hydroxy-1-methoxycarbonyl-6-methylxanthone (6), and isoconiochaetone C (7). Among the isolated compounds, compounds 2–5 significantly decreased fMLP-induced superoxide anion generation by human neutrophils, with IC50 values of 6.39 ± 0.40, 8.28 ± 0.29, 3.62 ± 0.61, and 2.67 ± 0.10 μM, respectively. Compounds 3 and 4 exhibited cytotoxic activities with IC50 values of 43.82 ± 6.33 and 32.29 ± 4.83 μM, respectively, against non-small lung cancer cell (A549), and Western blot assay confirmed that compounds 3 and 4 markedly induced apoptosis of A549 cells, through Bcl-2, Bax, and caspase 3 signaling cascades. |
| Starting Page | 25 |
| e-ISSN | 16603397 |
| DOI | 10.3390/md19010025 |
| Journal | Marine drugs |
| Issue Number | 1 |
| Volume Number | 19 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-01-08 |
| Access Restriction | Open |
| Subject Keyword | Marine drugs Marine Drugs Integrative and Complementary Medicine Penicillium Citrinum Chromone Derivatives Anti-inflammatory Activity Anti-cancer Activity |
| Content Type | Text |
| Resource Type | Article |
