NDLI: Mediator Effect of Cardiorespiratory Fitness on the Association between Physical Activity and Lung Function in Adults: Cross-Sectional Results from the Epimov Study

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Mediator Effect of Cardiorespiratory Fitness on the Association between Physical Activity and Lung Function in Adults: Cross-Sectional Results from the Epimov Study

Content Provider	MDPI
Author	Ostolin, Thatiane Lopes Valentim Di Paschoale Gonze, Bárbara De Barros Sperandio, Evandro Fornias Arantes, Rodolfo Leite Romiti, Marcello Dourado, Victor Zuniga
Copyright Year	2022
Abstract	We investigated whether cardiorespiratory fitness (CRF) mediates the association between moderate-to-vigorous physical activity (MVPA) and lung function in asymptomatic adults. We examined the cross-sectional results of 1362 adults aged 18–80 years from the Epidemiology and Human Movement Study. Participants were submitted to spirometry to obtain forced vital capacity (FVC) and forced expiratory volume in 1s (FEV1). Additionally, we used cardiopulmonary exercise testing to obtain peak oxygen uptake ( $\dot{V}$ O₂) as a measure of CRF. Participants used a triaxial accelerometer for 4–7 days to obtain MVPA. Mediation analyses were performed considering the CRF as a mediator, MVPA as an independent variable, and FVC and FEV1 as dependent variables with adjustment for age, sex, and cardiovascular risk score. We aimed to investigate the total (path c) and direct (paths a, b, c’) effects through the regression coefficients. We also examined the indirect effect, which was obtained from the product of the coefficients (path ab). Our sample was composed mainly of overweight and middle-aged women. MVPA was positively related to CRF (path a), as well as CRF and lung function (path b). MVPA also presented a significant positive total effect (path c) in the lung function. However, this relationship became non-significant when CRF was included in the model for both FVC and FEV1 (path c’). We did not observe a direct effect of MVPA on the lung function. In contrast, the indirect effect was significant (path ab). Lastly, CRF mediated 60% of the total effect of MVPA on FVC and 61.9% on FEV1. CRF mediates the relationship between lung function and MVPA in asymptomatic adults. Therefore, our results reinforce the need to include CRF assessment in practice clinical routine and suggest that strategies focusing on CRF might be more promising to prevent respiratory diseases in adults.
Starting Page	9377
e-ISSN	16604601
DOI	10.3390/ijerph19159377
Journal	International Journal of Environmental Research and Public Health
Issue Number	15
Volume Number	19
Language	English
Publisher	MDPI
Publisher Date	2022-07-31
Access Restriction	Open
Subject Keyword	International Journal of Environmental Research and Public Health Gerontology Physical Fitness Spirometry Cardiopulmonary Exercise Test Vital Capacity
Content Type	Text
Resource Type	Article

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