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Chemical Profile, Cytotoxic Activity and Oxidative Stress Reduction of Different Syringa vulgaris L. Extracts
| Content Provider | MDPI |
|---|---|
| Author | Ștefan, Răzvan Hanganu, Daniela Niculae, Mihaela Ielciu, Irina Olah, Neli-Kinga Munteanu, Melania Burtescu, Ramona Olar, Loredana Pall, Emoke Andrei, Sanda Vodnar, Dan Benedec, Daniela Oniga, Ilioara |
| Copyright Year | 2021 |
| Description | Syringa vulgaris L. (common lilac) is one of the most popular ornamental species, but also a promising not comprehensively studied source of bioactive compounds with important therapeutic potential. Our study was designed to characterize the chemical composition and to assess the antioxidant and cytotoxic properties of ethanolic extracts obtained from S. vulgaris L. flowers, leaves, bark, and fruit. The chemical profile of the ethanolic extracts was investigated using chromatographic $(HPLC-DAD-ESI^{+}$, GC-MS) and spectral (UV-Vis, FT-IR) methods, while the protective effect against free radicals was evaluated in vitro by different chemical assays (DPPH, FRAP, CUPRAC). The cytotoxic activity was tested on two tumoral cell lines, HeLa, B16F10, using the MTT assay. Significant amounts of free or glycosylated chemical components belonging to various therapeutically important structural classes, such as phenyl-propanoids (syringin, acteoside, echinacoside), flavonoids (quercetin, kaempferol derivatives) and secoiridoids (secologanoside, oleuropein, 10-hydroxy oleuropein, demethyloleuropein, syringalactone A, nuzhenide, lingstroside) were obtained for the flowers, leaves and bark extracts, respectively. Furthermore, MTT tests pointed out a significant cytotoxic potential expressed in a non-dose-dependent manner toward the tumoral lines. The performed methods underlined that S. vulgaris extracts, in particular belonging to flowers and leaves, represent valuable sources of compounds with antioxidant and antitumoral potential. |
| Starting Page | 3104 |
| e-ISSN | 14203049 |
| DOI | 10.3390/molecules26113104 |
| Journal | Molecules |
| Issue Number | 11 |
| Volume Number | 26 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-05-22 |
| Access Restriction | Open |
| Subject Keyword | Molecules Integrative and Complementary Medicine Syringa Vulgaris L. Flowers Bark Leaves Fruit Oleaceae Polyphenols Secoiridoids Antioxidant Cytotoxic |
| Content Type | Text |
| Resource Type | Article |
