NDLI: Circulating Tumor DNA Detection by Digital-Droplet PCR in Pancreatic Ductal Adenocarcinoma: A Systematic Review

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Circulating Tumor DNA Detection by Digital-Droplet PCR in Pancreatic Ductal Adenocarcinoma: A Systematic Review

Content Provider	MDPI
Author	Susana, Roselló Clara, Alfaro-Cervelló Marina, Garcés-Albir Huerta, Marisol Sabater, Luis Ferrer, Ana Tarazona, Noelia Roda, Desamparados Gambardella, Valentina Cervantes, Andrés Ibarrola-Villava, Maider
Copyright Year	2021
Description	Pancreatic cancer (PC) is one of the most devastating malignant tumors, being the seventh leading cause of cancer-related death worldwide. Researchers and clinicians are endeavoring to develop strategies for the early detection of the disease and the improvement of treatment results. Adequate biopsy is still challenging because of the pancreas’s poor anatomic location. Recently, circulating tumor DNA (ctDNA) could be identified as a liquid biopsy tool with huge potential as a non-invasive biomarker in early diagnosis, prognosis and management of PC. ctDNA is released from apoptotic and necrotic cancer cells, as well as from living tumor cells and even circulating tumor cells, and it can reveal genetic and epigenetic alterations with tumor-specific and individual mutation and methylation profiles. However, ctDNA sensibility remains a limitation and the accuracy of ctDNA as a biomarker for PC is relatively low and cannot be currently used as a screening or diagnostic tool. Increasing evidence suggests that ctDNA is an interesting biomarker for predictive or prognosis studies, evaluating minimal residual disease, longitudinal follow-up and treatment management. Promising results have been published and therefore the objective of our review is to understand the current role and the future perspectives of ctDNA in PC.
Starting Page	994
e-ISSN	20726694
DOI	10.3390/cancers13050994
Journal	Cancers
Issue Number	5
Volume Number	13
Language	English
Publisher	MDPI
Publisher Date	2021-02-27
Access Restriction	Open
Subject Keyword	Cancers Oncology Ctdna Digital-droplet Pcr (ddpcr) Pancreatic Cancer Pancreatic Ductal Adenocarcinoma (pdac)
Content Type	Text
Resource Type	Article

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