NDLI: Macrophages as a Therapeutic Target in Metastatic Prostate Cancer: A Way to Overcome Immunotherapy Resistance?

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Macrophages as a Therapeutic Target in Metastatic Prostate Cancer: A Way to Overcome Immunotherapy Resistance?

Content Provider	MDPI
Author	Martori, Clara Sanchez-Moral, Lidia Paul, Tony Pardo, Juan Carlos Font, Albert de Porras, Vicenç Ruiz Sarrias, Maria-Rosa
Copyright Year	2022
Description	Prostate cancer (PC) is the most common malignancy and the fifth cause of cancer death in men. The treatment for localized or locally advanced stages offers a high probability of cure. Even though the therapeutic landscape has significantly improved over the last decade, metastatic PC (mPC) still has a poor prognosis mainly due to the development of therapy resistance. In this context, the use of immunotherapy alone or in combination with other drugs has been explored in recent years. However, T-cell directed immune checkpoint inhibitors (ICIs) have shown limited activity with inconclusive results in mPC patients, most likely due to the highly immunosuppressive PC tumor microenvironment (TME). In this scenario, targeting macrophages, a highly abundant immunosuppressive cell type in the TME, could offer a new therapeutic strategy to improve immunotherapy efficacy. In this review, we summarize the growing field of macrophage-directed immunotherapies and discuss how these could be applied in the treatment of mPC, focusing on their combination with ICIs.
Starting Page	440
e-ISSN	20726694
DOI	10.3390/cancers14020440
Journal	Cancers
Issue Number	2
Volume Number	14
Language	English
Publisher	MDPI
Publisher Date	2022-01-16
Access Restriction	Open
Subject Keyword	Cancers Oncology Metastatic Prostate Cancer Immunotherapy Immune Checkpoint Inhibitors Tumor-associated Macrophages Tumor Microenvironment Immunotherapy Resistance
Content Type	Text
Resource Type	Article

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