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Potential Parasitic Causes of Epilepsy in an Onchocerciasis Endemic Area in the Ituri Province, Democratic Republic of Congo
| Content Provider | MDPI |
|---|---|
| Author | Vieri, Melissa Mandro, Michel Cardellino, Chiara Orza, Pierantonio Ronzoni, Niccolò Fodjo, Joseph Siewe Hotterbeekx, An Colebunders, Robert |
| Copyright Year | 2021 |
| Description | A high burden of epilepsy is observed in Africa where parasitological infections are endemic. In 2016, in an Onchocerciasis endemic area in the Logo health zone, in Ituri province in the Democratic Republic of Congo, a door-to-door study showed an epilepsy prevalence of 4.6%, and 50.6% of persons with epilepsy were infected with Onchocerca volvulus. In the current study, the serum of 195 people infected with O. volvulus persons with epilepsy were tested to determine the proportion of co-infections with Taenia solium, Toxocara canis and Strongyloides. These proportions were, respectively, 8.2, 18.5 and 12.8%. Persons with a T. solium co-infection were older than those without co-infection (p = 0.021). In six (37.5%) of the T. solium co-infected persons, the first seizures appeared after the age of 30 years compared to three (2.1%) persons without a co-infection (p < 0.0001). Our study suggests that an O. volvulus infection is the main parasitic cause of epilepsy in the Ituri province, but in some persons, mainly in those with late onset epilepsy and with focal seizures, the epilepsy may be caused by neurocysticercosis. As the population in the area rears pigs, activities to limit T. solium transmission should be implemented. |
| Starting Page | 359 |
| e-ISSN | 20760817 |
| DOI | 10.3390/pathogens10030359 |
| Journal | Pathogens |
| Issue Number | 3 |
| Volume Number | 10 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-03-18 |
| Access Restriction | Open |
| Subject Keyword | Pathogens Tropical Medicine River Epilepsy Onchocerciasis Onchocerca Volvulus Taenia Solium Strongyloides Toxocara Canis Democratic Republic of the Congo |
| Content Type | Text |
| Resource Type | Article |
