NDLI: Prognostic Role of Pre-Treatment $[^{18}$F]FDG PET/CT in Patients with Anaplastic Thyroid Cancer

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Prognostic Role of Pre-Treatment $[^{18}$F]FDG PET/CT in Patients with Anaplastic Thyroid Cancer

Content Provider	MDPI
Author	Kim, Hyun Jeong Chang, Hang-Seok Ryu, Young Hoon
Copyright Year	2021
Description	Anaplastic thyroid carcinoma (ATC) is a rare but highly lethal disease. Therefore, its diagnosis at an early stage and a rapid and accurate establishment of a proper treatment strategy is warranted. Tumor glycolysis assessed by$ ^{18}$fluorodeoxyglucose $([^{18}$F]FDG) positron emission tomography (PET)/computed tomography (CT) is predictive of many cancers despite its limited proven applicability to ATC. We investigated the prognostic capability of $[^{18}$F]FDG PET/CT in patients with ATC. Forty patients with ATC were subjected to $[^{18}$F]FDG PET/CT for pre-treatment evaluation. The tumor size and stage, overall survival (OS), and PET parameters, including the maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were analyzed. The 1-year OS rate was 17.5% with a mean life expectancy of 7.1 months. Distant metastasis was detected solely using PET/CT in 37.5% of cases. High SUVmax, MTV, and TLG were significantly associated with poor prognosis (p < 0.001, p = 0.002, and p < 0.001, respectively). A significant difference (p < 0.001) was observed in OS between patients with a high and low tumor SUVmax. Glucose metabolism assessed by $[^{18}$F]FDG PET/CT was significantly associated with the OS of patients with ATC. PET-derived parameters such as SUVmax, MTV, and TLG are useful prognostic biomarkers for ATC.
Starting Page	4228
e-ISSN	20726694
DOI	10.3390/cancers13164228
Journal	Cancers
Issue Number	16
Volume Number	13
Language	English
Publisher	MDPI
Publisher Date	2021-08-23
Access Restriction	Open
Subject Keyword	Cancers Endocrinology and Metabolism Anaplastic Thyroid Carcinoma [18f]fdg Pet/ct Prognosis Glycolysis
Content Type	Text
Resource Type	Article

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