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Molecular and Cellular Mechanisms of Vascular Development in Zebrafish
| Content Provider | MDPI |
|---|---|
| Author | Eberlein, Jean Herdt, Lukas Malchow, Julian Rittershaus, Annegret Baumeister, Stefan Helker, Christian Sm |
| Copyright Year | 2021 |
| Description | The establishment of a functional cardiovascular system is crucial for the development of all vertebrates. Defects in the development of the cardiovascular system lead to cardiovascular diseases, which are among the top 10 causes of death worldwide. However, we are just beginning to understand which signaling pathways guide blood vessel growth in different tissues and organs. The advantages of the model organism zebrafish (Danio rerio) helped to identify novel cellular and molecular mechanisms of vascular growth. In this review we will discuss the current knowledge of vasculogenesis and angiogenesis in the zebrafish embryo. In particular, we describe the molecular mechanisms that contribute to the formation of blood vessels in different vascular beds within the embryo. |
| Starting Page | 1088 |
| e-ISSN | 20751729 |
| DOI | 10.3390/life11101088 |
| Journal | Life |
| Issue Number | 10 |
| Volume Number | 11 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-10-15 |
| Access Restriction | Open |
| Subject Keyword | Life Peripheral Vascular Disease Zebrafish Vasculogenesis Angiogenesis Blood Vessels Endothelial Cells Signaling Pathways Vegf Apelin |
| Content Type | Text |
| Resource Type | Article |
