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The Biomarker and Therapeutic Potential of Circular Rnas in Schizophrenia
| Content Provider | MDPI |
|---|---|
| Author | Nedoluzhko, Artem Gruzdeva, Natalia Sharko, Fedor Rastorguev, Sergey Zakharova, Natalia Kostyuk, Georgy Ushakov, Vadim |
| Copyright Year | 2020 |
| Description | Circular RNAs (circRNAs) are endogenous, single-stranded, most frequently non-coding RNA (ncRNA) molecules that play a significant role in gene expression regulation. Circular RNAs can affect microRNA functionality, interact with RNA-binding proteins (RBPs), translate proteins by themselves, and directly or indirectly modulate gene expression during different cellular processes. The affected expression of circRNAs, as well as their targets, can trigger a cascade of events in the genetic regulatory network causing pathological conditions. Recent studies have shown that altered circular RNA expression patterns could be used as biomarkers in psychiatric diseases, including schizophrenia (SZ); moreover, circular RNAs together with other cell molecules could provide new insight into mechanisms of this disorder. In this review, we focus on the role of circular RNAs in the pathogenesis of SZ and analyze their biomarker and therapeutic potential in this disorder. |
| Starting Page | 2238 |
| e-ISSN | 20734409 |
| DOI | 10.3390/cells9102238 |
| Journal | Cells |
| Issue Number | 10 |
| Volume Number | 9 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2020-10-04 |
| Access Restriction | Open |
| Subject Keyword | Cells Psychiatry and Mental Health Circular Rnas Circrnas Micrornas Rbps Sponge Expression Biomarkers Therapy Schizophrenia |
| Content Type | Text |
| Resource Type | Article |
