NDLI: Cytoreductive Nephrectomy and Overall Survival of Patients with Metastatic Renal Cell Carcinoma Treated with Targeted Therapy—Data from the National Renis Registry

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Cytoreductive Nephrectomy and Overall Survival of Patients with Metastatic Renal Cell Carcinoma Treated with Targeted Therapy—Data from the National Renis Registry

Content Provider	MDPI
Author	Poprach, Alexandr Holanek, Milos Chloupkova, Renata Lakomy, Radek Stanik, Michal Fiala, Ondrej Melichar, Bohuslav Kopeckova, Katerina Zemanova, Milada Kiss, Igor Penka, Igor Bohosova, Julia Buchler, Tomas
Copyright Year	2020
Description	The role of cytoreductive nephrectomy (CN) in treatment of locally advanced or metastatic renal cell carcinoma (mRCC) in the era of targeted therapies (TT) is still not clearly defined. The study population consisted of 730 patients with synchronous mRCC. The RenIS (Renal carcinoma Information System) registry was used as the data source. The CN/TT cohort included patients having CN within 3 months from the mRCC diagnosis and subsequently being treated with TT, while the TT cohort included patients receiving TT upfront. Median progression-free survival from the first intervention was 6.7 months in the TT arm and 9.3 months in the CN/TT patients (p < 0.001). Median overall survival was 14.2 and 27.2 months, respectively (p < 0.001). Liver metastasis, high-grade tumor, absence of CN, non-clear cell histology, and MSKCC (Memorial Sloan-Kettering Cancer Center) poor prognosis status were associated with adverse treatment outcomes. According to the results of this retrospective study, patients who underwent CN and subsequently were treated with TT had better outcomes compared to patients treated with upfront TT. The results of the study support the use of CN in the treatment algorithm for mRCC.
Starting Page	2911
e-ISSN	20726694
DOI	10.3390/cancers12102911
Journal	Cancers
Issue Number	10
Volume Number	12
Language	English
Publisher	MDPI
Publisher Date	2020-10-10
Access Restriction	Open
Subject Keyword	Cancers Urology and Nephrology Metastatic Renal Cell Carcinoma Targeted Therapy Cytoreductive Nephrectomy Overall Survival
Content Type	Text
Resource Type	Article

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