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High-Dose Vitamin C for Cancer Therapy
| Content Provider | MDPI |
|---|---|
| Author | Vuk, Uskoković Mussa, Ali Idris, Ros Akmal Mohd Ahmed, Naveed Ahmad, Suhana Murtadha, Ahmad Hafiz Din, Tengku Ahmad Damitri Al Astani Tengku Yean, Chan Yean Rahman, Wan Faiziah Wan Abdul Lazim, Norhafiza Mat Hajissa, Khalid Mokhtar, Noor Fatmawati Mohamud, Rohimah Hassan, Rosline |
| Copyright Year | 2022 |
| Description | In recent years, the idea that Vitamin C (Vit-C) could be utilized as a form of anti-cancer therapy has generated many contradictory arguments. Recent insights into the physiological characteristics of Vit-C, its pharmacokinetics, and results from preclinical reports, however, suggest that high-dose Vit-C could be effectively utilized in the management of various tumor types. Studies have shown that the pharmacological action of Vit-C can attack various processes that cancerous cells use for their growth and development. Here, we discuss the anti-cancer functions of Vit-C, but also the potential for the use of Vit-C as an epigenetic regulator and immunotherapy enhancer. We also provide a short overview of the current state of systems for scavenging reactive oxygen species (ROS), especially in the context of their influencing high-dose Vit-C toxicity for the inhibition of cancer growth. Even though the mechanisms of Vit-C action are promising, they need to be supported with robust randomized and controlled clinical trials. Moreover, upcoming studies should focus on how to define the most suitable cancer patient populations for high-dose Vit-C treatments and develop effective strategies that combine Vit-C with various concurrent cancer treatment regimens. |
| Starting Page | 711 |
| e-ISSN | 14248247 |
| DOI | 10.3390/ph15060711 |
| Journal | Pharmaceuticals |
| Issue Number | 6 |
| Volume Number | 15 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-06-03 |
| Access Restriction | Open |
| Subject Keyword | Pharmaceuticals High-dose Anti-cancer Vitamin-c Pharmacological Pharmacokinetics Cancer Immunotherapy Ros-scavenging Systems |
| Content Type | Text |
| Resource Type | Article |
