Loading...
Please wait, while we are loading the content...
Similar Documents
Zika Brazilian Cohorts (ZBC) Consortium: Protocol for an Individual Participant Data Meta-Analysis of Congenital Zika Syndrome after Maternal Exposure during Pregnancy
| Content Provider | MDPI |
|---|---|
| Author | Thalia, Araújo Alecrim, Maria Amorim, Melania Brickley, Elizabeth Castilho, Marcia Coelho, Bernadete Cunha, Antônio Duarte, Geraldo Estofolete, Cássia Gurgel, Ricardo Herrero-Silva, Juliana Hofer, Cristina Lopes, Aline Martelli, Celina Melo, Adriana Miranda-Filho, Demócrito Montarroyos, Ulisses Moreira, Maria Mussi-Pinhata, Marisa Oliveira, Consuelo Passos, Saulo Prata-Barbosa, Arnaldo Santos, Darci Schuler-Faccini, Lavínia Silva, Antônio Siqueira, Isadora Sousa, Patrícia Turchi, Marília Ximenes, Ricardo Zara, Ana |
| Copyright Year | 2021 |
| Description | Despite great advances in our knowledge of the consequences of Zika virus to human health, many questions remain unanswered, and results are often inconsistent. The small sample size of individual studies has limited inference about the spectrum of congenital Zika manifestations and the prognosis of affected children. The Brazilian Zika Cohorts Consortium addresses these limitations by bringing together and harmonizing epidemiological data from a series of prospective cohort studies of pregnant women with rash and of children with microcephaly and/or other manifestations of congenital Zika. The objective is to estimate the absolute risk of congenital Zika manifestations and to characterize the full spectrum and natural history of the manifestations of congenital Zika in children with and without microcephaly. This protocol describes the assembly of the Consortium and protocol for the Individual Participant Data Meta-analyses (IPD Meta-analyses). The findings will address knowledge gaps and inform public policies related to Zika virus. The large harmonized dataset and joint analyses will facilitate more precise estimates of the absolute risk of congenital Zika manifestations among Zika virus-infected pregnancies and more complete descriptions of its full spectrum, including rare manifestations. It will enable sensitivity analyses using different definitions of exposure and outcomes, and the investigation of the sources of heterogeneity between studies and regions. |
| Starting Page | 687 |
| e-ISSN | 19994915 |
| DOI | 10.3390/v13040687 |
| Journal | Viruses |
| Issue Number | 4 |
| Volume Number | 13 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-04-16 |
| Access Restriction | Open |
| Subject Keyword | Viruses Biochemical Research Cohort Zika Pregnant Women Microcephaly Congenital Zika Syndrome Ipd Meta-analysis |
| Content Type | Text |
| Resource Type | Article |
