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Acute Dental Periapical Abscess and New-Onset Atrial Fibrillation: A Nationwide, Population-Based Cohort Study
| Content Provider | MDPI |
|---|---|
| Author | Hassan, Amaar Lip, Gregory Bisson, Arnaud Herbert, Julien Bodin, Alexandre Fauchier, Laurent Harris, Rebecca |
| Copyright Year | 2021 |
| Description | There are limited data on the relationship of acute dental infections with hospitalisation and new-onset atrial fibrillation (AF). This study aimed to assess the relationship between acute periapical abscess and incident AF. This was a retrospective cohort study from a French national database of patients hospitalized in 2013 (3.4 million patients) with at least five years of follow up. In total, 3,056,291 adults (55.1% female) required hospital admission in French hospitals in 2013 while not having a history of AF. Of 4693 patients classified as having dental periapical abscess, 435 (9.27%) developed AF, compared to 326,241 (10.69%) without dental periapical abscess that developed AF over a mean follow-up of 4.8 ± 1.7 years. Multivariable analysis indicated that dental periapical abscess acted as an independent predictor for new onset AF (p < 0.01). The $CHA_{2}DS_{2}$VASc score in patients with acute dental periapical abscess had moderate predictive value for development of AF, with Area Under the Curve (AUC) 0.73 (95% CI, 0.71–0.76). An increased risk of new onset AF was identified for individuals hospitalized with dental periapical abscess. Careful follow up of patients with severe, acute dental periapical infections is needed for incident AF, as well as investigations of possible mechanisms linking these conditions. |
| Starting Page | 2927 |
| e-ISSN | 20770383 |
| DOI | 10.3390/jcm10132927 |
| Journal | Journal of clinical medicine |
| Issue Number | 13 |
| Volume Number | 10 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-06-30 |
| Access Restriction | Open |
| Subject Keyword | Journal of clinical medicine Journal of Clinical Medicine Dentistry and Oral Surgery Atrial Fibrillation Periapical Abscess Oral Health Acute Dental Infection Cardiovascular Disease |
| Content Type | Text |
| Resource Type | Article |
