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Liquid Biopsies in Hepatocellular Carcinoma: Are We Winning?
| Content Provider | MDPI |
|---|---|
| Author | Andr, é L. Simão Artur, Słomka Aliona, Wöhler Mocan, Tudor Castro, Rui E. Rodrigues, Cecília M. P. Wang, Bingduo Strassburg, Christian Willms, Arnulf G. Kornek, Miroslaw |
| Copyright Year | 2020 |
| Description | Hepatocellular carcinoma (HCC) represents the sixth most common cancer worldwide and the third most common cause of cancer-related death. One of the major problems faced by researchers and clinicians in this area is the lack of reliable disease biomarkers, which would allow for an earlier diagnosis, follow-up or prediction of treatment response, among others. In this regard, the “HCC circulome”, defined as the pool of circulating molecules in the bloodstream derived from the primary tumor, represents an appealing target, the so called liquid biopsy. Such molecules encompass circulating tumor proteins, circulating tumor cells (CTCs), extracellular vesicles (EVs), tumor-educated platelets (TEPs), and circulating tumor nucleic acids, namely circulating tumor DNA (ctDNA) and circulating tumor RNA (ctRNA). In this article, we summarize recent findings highlighting the promising role of liquid biopsies as novel potential biomarkers in HCC, emphasizing on its clinical performance. |
| Starting Page | 1541 |
| e-ISSN | 20770383 |
| DOI | 10.3390/jcm9051541 |
| Journal | Journal of clinical medicine |
| Issue Number | 5 |
| Volume Number | 9 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2020-05-20 |
| Access Restriction | Open |
| Subject Keyword | Journal of clinical medicine Journal of Clinical Medicine Gastroenterology and Hepatology Biomarker Circulating Tumor Nucleic Acids Circulating Tumor Cells Extracellular Vesicles Proteomics and Metabolomics |
| Content Type | Text |
| Resource Type | Article |
