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Syntheses and Applications of 1,2,3-Triazole-Fused Pyrazines and Pyridazines
| Content Provider | MDPI |
|---|---|
| Author | Hoffman, Gavin R. Schoffstall, Allen M. |
| Copyright Year | 2022 |
| Description | Pyrazines and pyridazines fused to 1,2,3-triazoles comprise a set of heterocycles obtained through a variety of synthetic routes. Two typical modes of constructing these heterocyclic ring systems are cyclizing a heterocyclic diamine with a nitrite or reacting hydrazine hydrate with dicarbonyl 1,2,3-triazoles. Several unique methods are known, particularly for the synthesis of 1,2,3-triazolo[1,5-a]pyrazines and their benzo-fused quinoxaline and quinoxalinone-containing analogs. Recent applications detail the use of these heterocycles in medicinal chemistry (c-Met inhibition or $GABA_{A}$ modulating activity) as fluorescent probes and as structural units of polymers. |
| Starting Page | 4681 |
| e-ISSN | 14203049 |
| DOI | 10.3390/molecules27154681 |
| Journal | Molecules |
| Issue Number | 15 |
| Volume Number | 27 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-07-22 |
| Access Restriction | Open |
| Subject Keyword | Molecules Synthesis 1,2,3-triazole Fused 1,2,3-triazole 1,2,3-triazolo[4,5-b]pyrazine 1,2,3-triazolo[4,5-c]pyridazine 1,2,3-triazolo[4,5-d]pyridazine 1,2,3-triazolo[1,5-a]pyrazine 1,2,3-triazolo[1,5-b]pyridazine Triazolopyrazine Triazolopyridazine Practical Applications |
| Content Type | Text |
| Resource Type | Article |
