NDLI: Antiviral, Antibacterial, Antifungal, and Cytotoxic Silver(I) BioMOF Assembled from 1,3,5-Triaza-7-Phoshaadamantane and Pyromellitic Acid

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Antiviral, Antibacterial, Antifungal, and Cytotoxic Silver(I) BioMOF Assembled from 1,3,5-Triaza-7-Phoshaadamantane and Pyromellitic Acid

Content Provider	MDPI
Author	Jaros, ław Król Barbara, Bażanów Aleksander, Chrószcz Piotr, Smoleński Jaros, Sabina W. Poradowski, Dominik Nesterov, Dmytro S. Kirillov, Alexander M.
Copyright Year	2020
Description	The present study reports the synthesis, characterization, and crystal structure of a novel bioactive metal-organic framework, [Ag4(µ-PTA)2(µ3-PTA)2(µ4-pma)(H2O)2]n·6nH2O (bioMOF 1), which was assembled from silver(I) oxide, 1,3,5-triaza-7-phosphaadamantane (PTA), and pyromellitic acid (H4pma). This product was isolated as a stable microcrystalline solid and characterized by standard methods, including elemental analysis, 1H and 31P{1H} NMR and FTIR spectroscopy, and single crystal X-ray diffraction. The crystal structure of 1 disclosed a very complex ribbon-pillared 3D metal-organic framework driven by three different types of bridging ligands (µ-PTA, µ3-PTA, and µ4-pma4−). Various bioactivity characteristics of bioMOF 1 were investigated, revealing that this compound acts as a potent antimicrobial against pathogenic strains of standard Gram-negative (Escherichia coli, Pseudomonas aeruginosa) and Gram-positive (Staphylococcus aureus) bacteria, as well as a yeast (Candida albicans). Further, 1 showed significant antiviral activity against human adenovirus 36 (HAdV-36). Finally, bioMOF 1 revealed high cytotoxicity toward an abnormal epithelioid cervix carcinoma (HeLa) cell line with low toxicity toward a normal human dermal fibroblast (NHDF) cell line. This study not only broadens the family of PTA-based coordination polymers but also highlights their promising multifaceted bioactivity.
Starting Page	2119
e-ISSN	14203049
DOI	10.3390/molecules25092119
Journal	Molecules
Issue Number	9
Volume Number	25
Language	English
Publisher	MDPI
Publisher Date	2020-05-01
Access Restriction	Open
Subject Keyword	Molecules Inorganic Chemistry Metal-organic Frameworks Coordination Polymers Silver Complexes 1,3,5-triaza-7-phosphaadamantane Pyromellitic Acid Antimicrobial Activity Cytotoxic Activity Antiviral Activity
Content Type	Text
Resource Type	Article

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