NDLI: Lobularia libyca: Phytochemical Profiling, Antioxidant and Antimicrobial Activity Using In Vitro and In Silico Studies

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Lobularia libyca: Phytochemical Profiling, Antioxidant and Antimicrobial Activity Using In Vitro and In Silico Studies

Content Provider	MDPI
Author	Benchikha, Naima Chelalba, Imane Debbeche, Hanane Messaoudi, Mohammed Begaa, Samir Larkem, Imane Amara, Djilani Ghamem Rebiai, Abdelkrim Simal-Gandara, Jesus Sawicka, Barbara Atanassova, Maria Youssef, Fadia S.
Copyright Year	2022
Description	Lobularia libyca (L. libyca) is a traditional plant that is popular for its richness in phenolic compounds and flavonoids. The aim of this study was to comprehensively investigate the phytochemical profile by liquid chromatography, electrospray ionization and tandem mass spectrometry (LC-ESI-MS), the mineral contents and the biological properties of L. libyca methanol extract. L. libyca contains significant amounts of phenolic compounds and flavonoids. Thirteen compounds classified as flavonoids were identified. L. libyca is rich in nutrients such as Na, Fe and Ca. Moreover, the methanol extract of L. libyca showed significant antioxidant activity without cytotoxic activity on HCT116 cells (human colon cancer cell line) and HepG2 cells (human hepatoma), showing an inhibition zone of 13 mm in diameter. In silico studies showed that decanoic acid ethyl ester exhibited the best fit in β-lactamase and DNA gyrase active sites; meanwhile, oleic acid showed the best fit in reductase binding sites. Thus, it can be concluded that L. libyca can serve as a beneficial nutraceutical agent, owing to its significant antioxidant and antibacterial potential and due to its richness in iron, calcium and potassium, which are essential for maintaining a healthy lifestyle.
Starting Page	3744
e-ISSN	14203049
DOI	10.3390/molecules27123744
Journal	Molecules
Issue Number	12
Volume Number	27
Language	English
Publisher	MDPI
Publisher Date	2022-06-10
Access Restriction	Open
Subject Keyword	Molecules Integrative and Complementary Medicine Antioxidant Activity Antibacterial Activity L. Libyca Mineral Content Molecular Docking Total Flavonoid Total Phenol Content
Content Type	Text
Resource Type	Article

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