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Interaction of Mitochondrial Calcium and ROS in Neurodegeneration
| Content Provider | MDPI |
|---|---|
| Author | Baev, Artyom Y. Vinokurov, Andrey Y. Novikova, Irina N. Dremin, Viktor V. Potapova, Elena V. Abramov, Andrey Y. |
| Copyright Year | 2022 |
| Description | Neurodegenerative disorders are currently incurable devastating diseases which are characterized by the slow and progressive loss of neurons in specific brain regions. Progress in the investigation of the mechanisms of these disorders helped to identify a number of genes associated with familial forms of these diseases and a number of toxins and risk factors which trigger sporadic and toxic forms of these diseases. Recently, some similarities in the mechanisms of neurodegenerative diseases were identified, including the involvement of mitochondria, oxidative stress, and the abnormality of $Ca^{2+}$ signaling in neurons and astrocytes. Thus, mitochondria produce reactive oxygen species during metabolism which play a further role in redox signaling, but this may also act as an additional trigger for abnormal mitochondrial calcium handling, resulting in mitochondrial calcium overload. Combinations of these factors can be the trigger of neuronal cell death in some pathologies. Here, we review the latest literature on the crosstalk of reactive oxygen species and $Ca^{2+}$ in brain mitochondria in physiology and beyond, considering how changes in mitochondrial metabolism or redox signaling can convert this interaction into a pathological event. |
| Starting Page | 706 |
| e-ISSN | 20734409 |
| DOI | 10.3390/cells11040706 |
| Journal | Cells |
| Issue Number | 4 |
| Volume Number | 11 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-02-17 |
| Access Restriction | Open |
| Subject Keyword | Cells Neurosciences Neurodegeneration Mitochondria Calcium Reactive Oxygen Species Cell Death Permeability Transition Pore Neuron |
| Content Type | Text |
| Resource Type | Article |
