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Fabrication of Electrospun Juglans regia (Juglone) Loaded Poly(lactic acid) Scaffolds as a Potential Wound Dressing Material
| Content Provider | MDPI |
|---|---|
| Author | Altan, Eray Karacelebi, Yasin Saatcioglu, Elif Ulag, Songul Sahin, Ali Aksu, Burak Croitoru, Alexa-Maria Codrea, Cosmin Iulian Ficai, Denisa Gunduz, Oguzhan Ficai, Anton |
| Copyright Year | 2022 |
| Description | Juglone (5-hydroxy-1,4-naphthoquinone) (J) is a naphthoquinone structured allelochemical that is mostly found in the roots, leaves, nut-hulls, bark, and wood of walnut (Juglans regia). In this study, the biocompatibility, mechanical, thermal, chemical, morphological, and antimicrobial properties of the poly(lactic acid) (PLA) (w/v)/J (10, 20, 30 mg) electrospun scaffolds were investigated. Based on the results of the study, it was shown that juglone addition increased the antimicrobial properties of the scaffolds against the Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli), compared to the neat PLA film after 24 h of contact time. According to the tensile test results, the addition of J made the scaffolds more flexible but decreased the mechanical strength. The cytotoxicity properties of the J-added scaffolds demonstrated a toxic behavior on the first day of incubation. However, with an increase in the J ratio, the fibroblast cell metabolic activity increased for all incubation periods. |
| Starting Page | 1971 |
| e-ISSN | 20734360 |
| DOI | 10.3390/polym14101971 |
| Journal | Polymers |
| Issue Number | 10 |
| Volume Number | 14 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-05-12 |
| Access Restriction | Open |
| Subject Keyword | Polymers Dentistry and Oral Surgery Electrospinning Polylactic Acid Juglone Skin Tissue Engineering Wound Dressing |
| Content Type | Text |
| Resource Type | Article |
