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Effect of Central Obesity and Hyperandrogenism on Selected Inflammatory Markers in Patients with PCOS: A WHtR-Matched Case-Control Study
| Content Provider | MDPI |
|---|---|
| Author | Ma, łgorzata Kałużna Magdalena, Człapka-Matyasik Katarzyna, Wachowiak-Ochmańska Katarzyna, Piątek Marek, Ruchała Moczko, Jerzy Kaczmarek, Jolanta Janicki, Adam Ziemnicka, Katarzyna |
| Copyright Year | 2020 |
| Description | White blood cell counts (WBC), lymphocyte-to-monocyte ratio (LMR), and monocyte-to-high-density lipoprotein cholesterol ratio (MHR) are used as chronic inflammation markers. Polycystic ovary syndrome (PCOS) is a constellation of systemic inflammation linked to central obesity (CO), hyperandrogenism, insulin resistance, and metabolic syndrome. The waist-to-height ratio (WHtR) constitutes a highest-concordance anthropometric CO measure. This study aims to access WBC, LMR, and MHR in PCOS and healthy subjects, with or without CO. Establishing relationships between complete blood count parameters, high-sensitivity C-reactive protein (hsCRP), and hormonal, lipid and glucose metabolism in PCOS. To do this, WBC, LMR, MHR, hsCRP, anthropometric, metabolic, and hormonal data were analyzed from 395 women of reproductive age, with and without, PCOS. Correlations between MHR, and dysmetabolism, hyperandrogenism, and inflammation variables were examined. No differences were found in WBC, LMR, MHR, and hsCRP between PCOS and controls (p > 0.05). PCOS subjects with CO had higher hsCRP, MHR, and WBC, and lower LMR vs. those without CO (p < 0.05). WBC and MHR were also higher in controls with CO vs. without CO (p < 0.001). MHR correlated with anthropometric, metabolic, and endocrine parameters in PCOS. WHtR appeared to strongly predict MHR in PCOS. We conclude that PCOS does not independently influence WBC or MHR when matched for CO. CO and dysmetabolism may modify MHR in PCOS and control groups. |
| Starting Page | 3024 |
| e-ISSN | 20770383 |
| DOI | 10.3390/jcm9093024 |
| Journal | Journal of clinical medicine |
| Issue Number | 9 |
| Volume Number | 9 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2020-09-20 |
| Access Restriction | Open |
| Subject Keyword | Journal of clinical medicine Journal of Clinical Medicine Endocrinology and Metabolism Polycystic Ovary Syndrome (pcos) Systemic Inflammation Waist-to-height Ratio (whtr) White Blood Cell Counts (wbc) Lymphocyte-to-monocyte Ratio (lmr) Monocyte-to-high-density Lipoprotein Cholesterol Ratio (mhr) High-sensitivity C-reactive Protein (hscrp) Hyperandrogenism Insulin Resistance (ir) Metabolic Syndrome (ms) |
| Content Type | Text |
| Resource Type | Article |
