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The Wound-Healing Effect of Mango Peel Extract on Incision Wounds in a Murine Model
| Content Provider | MDPI |
|---|---|
| Author | Leticia, Garduño-Siciliano Espinosa-Espinosa, Lesslie Rodriguez-Canales, Mario Hernandez-Portilla, Luis Barbo Canales-Martinez, Maria Margarita Rodriguez-Monroy, Marco Aurelio |
| Copyright Year | 2022 |
| Description | Mangifera indica can generate up to 60% of polluting by-products, including peels. However, it has been shown that flavonoids and mangiferin are mainly responsible for the antioxidant, anti-inflammatory, and antibacterial activities closely related to the wound-healing process. The chemical composition of MEMI (methanolic extract of M. indica) was analyzed by HPLC-DAD, as well as concentrations of total phenol (TPC) and flavonoids (TFC) and antioxidant activity $(SA_{50}$). Wound-healing efficacy was determined by measurements of wound contraction, histological analysis, and tensiometric method; moreover, anti-inflammatory, antibacterial, and acute dermal toxicity (OECD 402) were also evaluated. Phenol, resorcinol, conjugated resorcinol, and mangiferin were detected. TPC, TFC, and $SA_{50}$ were 136 mg GAE/g, 101.66 mg QE/g, and 36.33 µg/mL, respectively. Tensile strength and wound contraction closure did not show significant differences between MEMI and dexpanthenol groups. Histological analysis (after 14 days) shows a similar architecture between MEMI treatment and normal skin. MEMI exhibits a reduction in edema. Staphylococcus epidermidis had an MIC of 2 mg/mL, while Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli reached 4 mg/mL. The MEMI showed no signs of toxicity. Therefore, this study demonstrates multiple targets that flavonoids and mangiferin of MEMI may present during the healing process. |
| Starting Page | 259 |
| e-ISSN | 14203049 |
| DOI | 10.3390/molecules27010259 |
| Journal | Molecules |
| Issue Number | 1 |
| Volume Number | 27 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-01-01 |
| Access Restriction | Open |
| Subject Keyword | Molecules Integrative and Complementary Medicine Mangifera Indica Peel Wound Healing Antibacterial Antioxidant |
| Content Type | Text |
| Resource Type | Article |
