NDLI: Thermosensitive Poly(DHSe/PEG/PPG Urethane)-Based Hydrogel Extended Remdesivir Application in Ophthalmic Medication

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Thermosensitive Poly(DHSe/PEG/PPG Urethane)-Based Hydrogel Extended Remdesivir Application in Ophthalmic Medication

Content Provider	MDPI
Author	Xu, Sennan Ke, Lingjie Zhao, Sichen Li, Zhiguo Xiao, Yang Wu, Yunlong Ren, Jie Qiu, Yan
Copyright Year	2021
Description	The spread of infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the coronavirus disease 2019 (COVID-19) outbreak beginning in March 2020. Currently, there is a lack of suitable dose formulations that interrupt novel coronavirus transmission via corneal and conjunctival routes. In the present study, we developed and evaluated a thermosensitive gelling system based on a selenium-containing polymer for topical ocular continuous drug release. In detail, di-(1-hydroxylundecyl) selenide (DHSe), poly(ethylene glycol) (PEG), and poly(propylene glycol) (PPG) were polymerized to form poly(DHSe/PEG/PPG urethane). The polymer was used to carry poorly water-soluble remdesivir (RDV) at room temperature to form the final thermosensitive in situ gel, which exhibited a typical sol-gel transition at 35 °C. The formed polymer was further characterized by rheology, thermology, and scanning electron microscopy. In vitro release studies and in vivo retention and penetration tests indicated that the thermogel provided the prolonged release of RDV. The RDV-loaded in situ gel was proven to be non-biotoxic against human corneal epithelial cells, with good ocular tolerance and biocompatibility in rabbit eyes.
Starting Page	50
e-ISSN	19994923
DOI	10.3390/pharmaceutics14010050
Journal	Pharmaceutics
Issue Number	1
Volume Number	14
Language	English
Publisher	MDPI
Publisher Date	2021-12-27
Access Restriction	Open
Subject Keyword	Pharmaceutics Pharmacology and Pharmacy Thermosensitive Hydrogel Remdesivir Ophthalmic Drug Delivery Ocular Retention Ocular Irritation
Content Type	Text
Resource Type	Article

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