NDLI: Multifunctional Tannic Acid-Alendronate Nanocomplexes with Antioxidant, Anti-Inflammatory, and Osteogenic Potency

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Multifunctional Tannic Acid-Alendronate Nanocomplexes with Antioxidant, Anti-Inflammatory, and Osteogenic Potency

Content Provider	MDPI
Author	Choi, Somang Jo, Han-Saem Song, Heegyeong Kim, Hak-Jun Oh, Jong-Keon Cho, Jae-Woo Park, Kyeongsoon Kim, Sung-Eun
Copyright Year	2021
Description	In the current study, we fabricated tannic acid-alendronate (TA-ALN) nanocomplexes (NPXs) via self-assembly. These TA-ALNs were characterized by dynamic light scattering, zeta potential, transmission electron microscopy, and FT-IR spectroscopy. The TA-ALNs were evaluated for antioxidant, anti-inflammatory, and osteogenesis-accelerating abilities in osteoblast-like cells (MC3T3-E1 cells). All TA-ALNs displayed nano-sized beads that were circular in form. Treatment with TA-ALN (1:0.1) efficiently removed reactive oxygen species in cells and protected osteoblast-like cells from toxic hydrogen peroxide conditions. Moreover, TA-ALN (1:0.1) could markedly decrease the mRNA levels of pro-inflammatory mediators in lipopolysaccharide-stimulated cells. Furthermore, cells treated with TA-ALN (1:1) exhibited not only significantly greater alkaline phosphatase activity and calcium collection, but also outstandingly higher mRNA levels of osteogenesis-related elements such as collagen type I and osteocalcin. These outcomes indicate that the prepared TA-ALNs are excellent for antioxidant, anti-inflammatory, and osteogenic acceleration. Accordingly, TA-ALN can be used latently for bone renovation and regeneration in people with bone fractures, diseases, or disorders.
Starting Page	1812
e-ISSN	20794991
DOI	10.3390/nano11071812
Journal	Nanomaterials
Issue Number	7
Volume Number	11
Language	English
Publisher	MDPI
Publisher Date	2021-07-13
Access Restriction	Open
Subject Keyword	Nanomaterials Cell Tissue Engineering Tannic Acid (ta) Alendronate (aln) Nanocomplexes (npxs) Ros Effect Inflammation Control Osteogenesis Acceleration
Content Type	Text
Resource Type	Article

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