Loading...
Please wait, while we are loading the content...
Similar Documents
Heat Shock Protein 90 (Hsp90) and Hsp70 as Potential Therapeutic Targets in Autoimmune Skin Diseases
| Content Provider | MDPI |
|---|---|
| Author | Tukaj, Stefan Sitko, Krzysztof |
| Copyright Year | 2022 |
| Description | Over a hundred different autoimmune diseases have been described to date, which can affect every organ in the body, including the largest one, the skin. In fact, up to one-fifth of the world’s population suffers from chronic, noninfectious inflammatory skin diseases, the development of which is significantly influenced by an autoimmune response. One of the hallmarks of autoimmune diseases is the loss of immune tolerance, which leads to the formation of autoreactive lymphocytes or autoantibodies and, consequently, to chronic inflammation and tissue damage. The treatment of autoimmune skin diseases mainly focuses on immunosuppression (using, e.g., corticosteroids) but almost never leads to the development of permanent mechanisms of immune tolerance. In addition, current therapies and their long-term administration may cause serious adverse effects. Hence, safer and more effective therapies that bring sustained balance between pro- and anti-inflammatory responses are still desired. Both intra- and extracellular heat shock proteins (Hsps), specifically well-characterized inducible Hsp90 and Hsp70 chaperones, have been highlighted as therapeutic targets for autoimmune diseases. This review presents preclinical data on the involvement of Hsp90 and Hsp70 in modulating the immune response, specifically in the context of the treatment of selected autoimmune skin diseases with emphasis on autoimmune bullous skin diseases and psoriasis. |
| Starting Page | 1153 |
| e-ISSN | 2218273X |
| DOI | 10.3390/biom12081153 |
| Journal | Biomolecules |
| Issue Number | 8 |
| Volume Number | 12 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2022-08-20 |
| Access Restriction | Open |
| Subject Keyword | Biomolecules Dermatology Heat Shock Proteins Hsp90 Hsp70 Skin Diseases Autoimmunity Therapy |
| Content Type | Text |
| Resource Type | Article |
