NDLI: Fused in Sarcoma (FUS) in DNA Repair: Tango with Poly(ADP-ribose) Polymerase 1 and Compartmentalisation of Damaged DNA

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Fused in Sarcoma (FUS) in DNA Repair: Tango with Poly(ADP-ribose) Polymerase 1 and Compartmentalisation of Damaged DNA

Content Provider	MDPI
Author	David, Pastré Sukhanova, Maria V. Singatulina, Anastasia S. Lavrik, Olga I.
Copyright Year	2020
Description	The fused in sarcoma (FUS) protein combines prion-like properties with a multifunctional DNA/RNA-binding domain and has functions spanning the regulation of RNA metabolism, including transcription, pre-mRNA splicing, mRNA transport and translation. In addition to its roles in RNA metabolism, FUS is implicated in the maintenance of DNA integrity. In this review, we examine the participation of FUS in major DNA repair pathways, focusing on DNA repair associated with poly(ADP-ribosyl)ation events and on how the interaction of FUS with poly(ADP-ribose) may orchestrate transient compartmentalisation of DNA strand breaks. Unravelling how prion-like RNA-binding proteins control DNA repair pathways will deepen our understanding of the pathogenesis of some neurological diseases and cancer as well as provide the basis for the development of relevant innovative therapeutic technologies. This knowledge may also extend the range of applications of poly(ADP-ribose) polymerase inhibitors to the treatment of neurodegenerative diseases related to RNA-binding proteins in the cell, e.g., amyotrophic lateral sclerosis and frontotemporal lobar degeneration.
Starting Page	7020
e-ISSN	14220067
DOI	10.3390/ijms21197020
Journal	International Journal of Molecular Sciences
Issue Number	19
Volume Number	21
Language	English
Publisher	MDPI
Publisher Date	2020-09-24
Access Restriction	Open
Subject Keyword	International Journal of Molecular Sciences Cell Tissue Engineering Fused in Sarcoma Dna Repair Poly(adp-ribose) Polymerase Poly(adp-ribose) Protein Phase Separation
Content Type	Text
Resource Type	Article

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