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Unveiling Cancer Metabolism through Spontaneous and Coherent Raman Spectroscopy and Stable Isotope Probing
| Content Provider | MDPI |
|---|---|
| Author | Xu, Jiabao Yu, Tong Zois, Christos Cheng, Ji-Xin Tang, Yuguo Harris, Adrian Huang, Wei |
| Copyright Year | 2021 |
| Description | Metabolic reprogramming is a common hallmark in cancer. The high complexity and heterogeneity in cancer render it challenging for scientists to study cancer metabolism. Despite the recent advances in single-cell metabolomics based on mass spectrometry, the analysis of metabolites is still a destructive process, thus limiting in vivo investigations. Being label-free and nonperturbative, Raman spectroscopy offers intrinsic information for elucidating active biochemical processes at subcellular level. This review summarizes recent applications of Raman-based techniques, including spontaneous Raman spectroscopy and imaging, coherent Raman imaging, and Raman-stable isotope probing, in contribution to the molecular understanding of the complex biological processes in the disease. In addition, this review discusses possible future directions of Raman-based technologies in cancer research. |
| Starting Page | 1718 |
| e-ISSN | 20726694 |
| DOI | 10.3390/cancers13071718 |
| Journal | Cancers |
| Issue Number | 7 |
| Volume Number | 13 |
| Language | English |
| Publisher | MDPI |
| Publisher Date | 2021-04-05 |
| Access Restriction | Open |
| Subject Keyword | Cancers Biomedical Engineering Cancer Metabolism Raman Spectroscopy Stimulated Raman Scattering Coherent Raman Anti-stokes Scattering Raman Imaging Lipid Metabolism Stable Isotope Probing |
| Content Type | Text |
| Resource Type | Article |
