NDLI: Evidence of BK Polyomavirus Infection in Urothelial but not Renal Tumors from a Single Center Cohort of Kidney Transplant Recipients

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Evidence of BK Polyomavirus Infection in Urothelial but not Renal Tumors from a Single Center Cohort of Kidney Transplant Recipients

Content Provider	MDPI
Author	Borgogna, Cinzia Albertini, Silvia Martuscelli, Licia Poletti, Filippo Volpe, Alessandro Merlotti, Guido Cantaluppi, Vicenzo Boldorini, Renzo Gariglio, Marisa
Copyright Year	2021
Description	Emerging evidence indicates that reactivation of BK polyomavirus (BKPyV) in the kidney and urothelial tract of kidney transplant recipients (KTRs) may be associated with cancer in these sites. In this retrospective study of a single center cohort of KTRs (n = 1307), 10 clear cell renal cell carcinomas and 5 urinary bladder carcinomas were analyzed from 15 KTRs for the presence of BKPyV infection through immunohistochemistry and fluorescent in situ hybridization (FISH). Three of these patients had already exhibited biopsy-proven polyomavirus-associated nephropathies (PyVAN). Although the presence of BKPyV large-T antigen was evident in the urothelium from a kidney removed soon after PyVAN diagnosis, it was undetectable in all the formalin-fixed and paraffin-embedded (FFPE) blocks obtained from the 10 kidney tumors. By contrast, large-T antigen (LT) labeling of tumor cells was detected in two out of five bladder carcinomas. Lastly, the proportion of BKPyV DNA-FISH-positive bladder carcinoma nuclei was much lower than that of LT-positive cells. Taken together, our findings further strengthen the association between BKPyV reactivation and cancer development in KTRs, especially bladder carcinoma.
Starting Page	56
e-ISSN	19994915
DOI	10.3390/v13010056
Journal	Viruses
Issue Number	1
Volume Number	13
Language	English
Publisher	MDPI
Publisher Date	2021-01-03
Access Restriction	Open
Subject Keyword	Viruses Pathology Bkpyv Pyvan Kidney Transplant Recipient Renal Cell Carcinoma Bladder Carcinoma
Content Type	Text
Resource Type	Article

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